摘要
目的 探索胃癌患者长期生存的机理。方法 采用病理组织学和免疫组织化学技术对比研究了 47例生存时间超过5年 (长生存组 )的胃癌患者和 44例生存时间在 2年以下 (短生存组 )的胃癌病例。结果 长生存组和短生存组患者在胃癌浸润深度方面比较无显著性差异 (P >0 .0 5 ) ;长生存组组织学类型主要为高分化腺癌 ,而短生存组多数为低分化腺癌 ,2组间有显著性差异 (P <0 .0 5 ) ;长生存组淋巴结转移病例 (44 .7% )明显少于短生存组 (72 .7% ) ;长生存组 p5 3和 p2 1阳性率 (分别为 36 .2 %和6 6 .0 % )明显低于短生存组 (分别为 5 6 .9%和 88.6 % ) ,具有显著性差异 (P <0 .0 5 )。结论 影响胃癌患者生存的因素 ,除了组织学类型、淋巴结转移等因素外 ,p5 3基因突变和 p2 1基因过度表达也是影响患者生存的因素 ,检测 p5 3基因和p2 1基因的表达情况有助于胃癌患者的预后判断。
Objective To investigate the factors of long time survival of the patients with gastric carcinoma.Methods 47 cases of long time survival and 44 cases of short time survival patients with gastric carcinoma were comparatively studied by pathohistology and immunohistochemistry.Results No significant difference in invasive depth of stomach was found between the long time survival and short time survival group( P >0.05).The most of the patients with long time survival had a well differentiated carcinoma,but the most of the patients with short time survival had an undifferentiated carcinoma( P <0.05).The metastasis of lymph nodes in long time survival group(44.7%) was significantly low than that in the short time survival group(72.7%, P <0.01).The positive rates of p53 and p21 in long time survival group(36.2% and 66.0%,respectively) were significantly lower than that in short time survival group(56.8% and 88.6%,respectively).Conclusion The survival time of the patients with gastric carcinoma was depend on the p53 gene mutation and p21 gene over expression,besides the pathohistologic types,lymphatic metastasis and so on.It is helpful for evaluating the prognosis of patients with gastric cancer to test the expression of p53 and p21.
出处
《实用癌症杂志》
2001年第1期64-66,共3页
The Practical Journal of Cancer
