摘要
目的 探讨胃癌组织中p16蛋白和血管内皮生长因子 (VEGF)的表达及其相关性。方法 应用S P免疫组织化学方法检测胃癌 16 0例、胃良性病变 5 2例组织中 p16蛋白及VEGF的表达。 结果 胃癌中的 p16蛋白表达率低于胃良性病变(P <0 .0 5 ) ,而VEGF表达率则高于胃良性病变 (P <0 .0 1)。胃癌中 p16蛋白的低表达与VEGF的高表达具有显著相关性 (P <0 .0 1)。结论 p16蛋白和VEGF在胃癌的发生、发展中起重要作用 ,两者具有相关性 ,是胃癌的生物学标记。
Objective To investigate the expression of p16 protein and VEGF in gastric carcinoma(GC) and it's relativity.Methods Expressions of p16 and VEGF were tested by S P immunohistochemistry of in 160 cases of gastric carcinoma(GC) and 52 cases of gastric benign disease(GBD).Results It was found that positive expression of p16 protein in gastric carcinoma(GC) was lower than in gastric benign disease(GBD)( P <0.05),but positive expression rate of VEGF in gastric carcinoma(GC) was higher than in gastric benign disease(GBD)( P <0.01).There was a significant relationship between p16 protein and VEGF expression( P <0.01).Conclusion The results suggest that p16 and VEGF is closely related to the occurrence and development of gastric carcinoma(GC).p16 and VEGF could be used as a biologic marker for gastric carcinoma(GC).There is significant relation between p16 protein and VEGF.
出处
《实用癌症杂志》
2001年第1期39-40,共2页
The Practical Journal of Cancer
关键词
胃肿瘤
P16蛋白
血管内皮生长因子
免疫组织化学
胃癌
Gastric carcinoma(GC)
p16 protein
Vascular endothelial growth factor(VEGF)
Immunohistochemist
