摘要
目的 评价血浆内皮素 1(endothelin 1,ET 1)和血清癌胚抗原 (CEA )的检测对非小细胞肺癌 (NSCLC )的诊断价值。方法 采用放射免疫法对 43例经临床诊断和病理证实的NSCLC患者和 2 0例正常人进行血浆ET 1和血清CEA测定。结果NSCLC血浆ET 1的阳性率为 5 5 .8% ,其中鳞癌阳性率为 6 0 .0 % ,腺癌阳性率为 5 5 .0 % ;NSCLC血清CEA的阳性率为 39.5 % ,其中腺癌为 5 5 .0 % ;联合检测血浆ET 1和血清CEA可将NSCLC诊断阳性率提高到 6 5 .1%。结论 两者联合检测有助于诊断NSCLC。
Objective To evaluate the diagnostic value of plasma endothelin 1(ET 1) and serum carcinoembryonic antigen(CEA) in non small cell lung cancer(NSCLC).Methods plasma ET 1 and serum CEA were measured with radioimmunoassay in 43 NSCLC patients and 20 healthy subjects;Among the patients,20 cases were squamous cell carcinoma,20 adeno carcinoma and 3 large cell carcinoma;Results were expressed by ±s , +2s of control plasma ET 1 was taken as upper limit to determine the ET 1 positive rate,15 μg/L as upper limit to determine the CEA positive rate.Results The positive rate of plasma ET 1 was 55.8% in NSCLC group,60.0% in squamous cell carcinoma group 55.0% in Adeno–carcinoma group.The positive rate of serum CEA in NSCLC group was 39.5%,in Adeno Carcinoma group,55.0%.The positive rate could be elevated to 65.1% in NSCLC group when plasma ET 1 and serum CEA were simutaneously detected.Conclusion Plasma ET 1 and serum SEA are beneficical markers in diagnosis of NSCLC.
出处
《实用癌症杂志》
2001年第1期24-26,共3页
The Practical Journal of Cancer
关键词
血浆
内皮素-1
血清癌胚抗原
非小细胞肺癌
放射免疫法
诊断
Plasma endothelin 1
Serum carcinoembryonic antigen
Non small cell lung cancer
Radio immunassay
