摘要
目的 研究随机微量尿白蛋白/肌酐比值（ACR）用于诊疗重度和轻度先兆子痫孕妇的最佳比例,分析随机微量尿白蛋白/肌酐比例与24 h尿蛋白定量是否具有显著相关性.方法选取2011年9月～2013年6月我院收治的先兆子痫孕妇60例,包括轻度先兆子痫孕妇42例,重度先兆子痫孕妇18例,分别用胱抑素免疫透射比浊法与酶法检测孕妇血清中胱抑素、血尿酸、血尿素氮、白蛋白和肌酐水平.结果经免疫透射比浊法与酶法检测得到轻度先兆子痫与重度先兆子痫都胱抑素水平分别为（1.3±0.3）mg/L、（1.6±0.5）mg/L,尿酸水平分别为（359.4±6.4）μmol/L、（450.2±8.3）μmol/L.通过微量蛋白分析仪的检测与计算得轻重先兆子痫孕妇平均尿白蛋白/肌酐比值分别为（72.7±8.3）mg/mmol、（401.6±14.9）mg/mmol.传统得放大检测轻重度先兆子痫孕妇平均24 h尿蛋白分别为（700.5±12.5）mg、（4800.0±45.0）mg.结论通过对轻重度先兆子痫孕妇患者的血清生化检测、尿白蛋白/肌酐比值和24 h尿蛋白定量对比分析、尿蛋白的定量关系进行分析,尿白蛋白/肌酐比值诊断轻度先兆子痫的最佳值为22.8 mg/mmol,诊断重度先兆子痫的最佳值为155.6 mg/mmol.
Objective To study the optimal ratio of random urine micro albumin/creatinine rate （ACR） in severe and mild preeclampsia diagnosis and treatment and to analyze whether there is a significant correlation between random urine micro albumin/creatinine rate and 24h urinary protein quantity. Methods Sixty pregnant patients with preeclampsia admitted to our hospital from September 2011 to June 2013 were chosen,among which 42 were mild preeclampsia and 18 were severe preeclampsia.Cystatin immunological transmission turbidimetry and GPO-PAP were used respec- tively to test the cystatin,blood uric acid, blood urea nitrogen, albumin and creatnine levels of the patient serum. Results Of the immunological transmission turbidimetry and GPO-PAP showed that the cystatin levels were （1.3±0.3）mg/L and （1.6±0.5）mg/L,and blood uric acid levels were （359.4±6.4）umol/L and （450.2±8.3）umol/L,for mild and severe preeelampsia patients respectively. According to the detection of trace protein analyzer and calculation,the average ACRs were （72.7±8.3）mg/mmol and （401.6±14.9）mg/mmol for mild and severe preeelampsia patients respectively. Traditional amplification detection showed that the 24h urinary protein quantities for mild and severe preeclampsia patients were （700.5 ± 12.5 ） mg and （4800.0±45.0） mg respectively. Conclusion According to the serum biochemical tests, the ACR and 24h urinary protein quantity comparative analysis and urinary protein quantity analysis for the mild and severe preeclampsia women, the optimal value of ACR is 22.8mg/mmol for diagnosing mild preeclampsia and 155.6mg/ mmol for diagnosing severe preeclampsia.
出处
《中国现代医生》
2014年第7期43-45,共3页
China Modern Doctor
关键词
随机尿
尿蛋白
先兆子痫
尿白蛋白
肌酐比
Random urine
Urine protein
Preeclampsia
Urine albumin/creatinine rate
