摘要
目的探讨神经节苷脂联合康复干预对高危儿脑损伤临床治疗效果。方法采用多组对照比较法,将160例高危儿脑损伤病例,按入院先后顺序分为对照组(A组)、康复干预组(B组)、神经节苷脂组(C组)、神经节苷脂联合康复干预组(D组),每组40例。4组均给予神经内科基础护理,A组不作其他处理;B组再给予康复干预治疗;C组再服用神经节苷脂20 mg/d,连服10 d;D组再给予B、C两组的联合治疗。对各组的临床疗效进行比较分析,并探讨年龄对治疗效果的影响。结果A、B、C、D组总有效率分别为5%、47.5%、50%、90%,D组与其余3组比较均有显著差异(P<0.05),B、C组间无显著差异(P>0.05),但显著高于A组(P<0.05)。患儿年龄与治疗有效率具有负相关性,年龄越小,治疗有效率越高。结论神经节苷脂联合康复干预对高危儿脑损伤治疗效果明显,具有很好的临床应用前景。
Objective To discuss the clinical treatment effects of ganglioside combined with rehabilitation intervention on high risk infants with brain injury. Methods Comparison among multiple groups was carried out. 160 high risk infants with brain injury were divided into group A, B, C, and D with 40 cases in each group. The four groups were given basic neurological care. Group A did not receive any other treatment;group B was given rehabilitation intervention;group C took ganglioside 20 mg/d for continuous l0 days;and group D received the combination treatment （ ganglioside ＋ rehabilitation intervention ）. The curative effects of those groups were compared and analyzed, and the influence of age on the therapeutic effect was discussed. Results The total effective rates of group A, B, C, and D were 5% ,47.5% , 50% , and 90% , respectively. There were significant differences between group D and the other three groups（ P 〈 0.05 ）. There was no significant difference between group B and C（ P 〉 0.05 ）, and the total effective rate of group A was the lowest （P 〈 0.05 ）. There was a negative correlation between the age and the effective rate. The smaller the age, the higher the curative rate. Conclusion Ganglioside combined with rehabilitation intervention have significant therapeutic effect on high risk infants with brain injury and also good clinical application effect.
出处
《西南国防医药》
CAS
2014年第2期178-180,共3页
Medical Journal of National Defending Forces in Southwest China
关键词
高危儿
脑损伤
神经节苷脂
康复干预
疗效
high risk infants
brain injury
ganglioside
rehabilitation intervention
curative effect
