摘要
目的 :探讨豚鼠耳蜗底回接近末端局部微循环障碍的听力损伤特点 ,建立以高频损伤为主的听力损伤模型。方法 :采用光化学法诱导豚鼠耳蜗底回接近末端 1/ 2段微循环障碍 ;常规火棉胶切片观察耳蜗形态学变化 ;Madsen2 2 5 0诱发电位系统记录各频率的耳蜗神经复合动作电位 (CAP)。结果 :各频率的 CAP N1 潜伏期、CAP阈移、CAP N1 振幅变化 ,提示其听力损伤以高频较重 ,组织病理学变化表明耳蜗形态学改变主要局限于耳蜗底回接近末端 1/ 2段。结论 :耳蜗底回接近末端局部微循环障碍可以导致高频范围为主的听力损伤。
Objective:To study the characteristics of hearing loss caused by local microcirculatory disorders in the cochlea basal turn near termination of guinea pigs.Method:The local microcirculatory disorders in the cochlea basal turn near termination of guinea pigs were caused by photochemical reaction;morphological changes were observed by light microscope;the CAP N 1 amplitude,CAP N 1 latency and CAP N 1 threshold shift which were evoked by short tone burst were recorded by Madsen 2250.Result:Morphological changes showed that histopathological changes were located in the basal turn near termination of cochlea.The CAP N 1 amplitude,CAP N 1 latency and CAP N 1 threshold shift showed that the hearing loss was remarkable in the high range frequencies.Conclusion:If the local microcirculatory disorders in the cochlea basal turn near termination take place,the hearing losses are more remarkable in the high range frequencies.
出处
《临床耳鼻咽喉科杂志》
CAS
CSCD
北大核心
2001年第1期23-25,共3页
Journal of Clinical Otorhinolaryngology
关键词
微循环障碍
耳蜗
高频听力损失
耳蜗电图
Microcirculatory disorders
Cochlea
High Frequency hearing loss
Electrocochleogram
