摘要
目的了解某院药品不良反应(ADR)发生的特点及引发ADR的相关因素,以促进临床合理用药。方法对某院2011年9月—2012年2月上报的130例ADR,就患者性别与年龄分布、给药途径、药品种类、ADR累及系统或器官、ADR发生时间、ADR程度分级、ADR因果关系评价及转归情况进行分析。结果 130例ADR中男74例,女56例,≥60岁人群ADR发生率最高(43.08%)。引起ADR的主要给药途径是静脉滴注,占70.77%。抗感染药物引发的ADR所占比例最高(48.61%)。ADR以皮肤及附件系统损害为主(32.82%)。ADR发生时间为用药后2 min^22 d。新的和严重的ADR占16.15%。96.15%的ADR可自愈或经相应处理后治愈、好转。结论临床应依据ADR发生的特点采取针对性预防措施,以降低ADR发生率,同时加强ADR的监测和上报工作。
Objective To investigate features and relative factors of adverse drug reactions （ADRs） found in our hospital in order to improve the rational administration in clinics. Methods Clinical data of 130 cases of ADR during September 2011 and February 2012 in our hospital was collected, and distributions of gender and age, administration routes, drug categories, involved systems and organs, occurrence time, ADR degree classifications, ADR causation eval- uation and outcomes were statistically analyzed. Results Among the 130 patients with ADR, there were 74 males and 56 females, and the highest incidence rate was found in elderly patients over 60 years old （43.08%）. The primary adminis- tration routes was intravenous drip （70.77%）. The ADR incidence induced by antimicrobial drugs was the top one （48.61%）. The main clinical manifestations were lesions of skin and its adnexal systems （32.82%）. The occurrence time was 2 min-22 d after medication. The percentage of primary and severe ADRs was 16.15%. A total of 96.15% of ADR cases were cured or relieved after corresponding treatments. Conclusion Clinicians should take corresponding pro- tective measures according to ADR characteristics to reduce the incidence rate of ADR, and reinforce monitoring and re- porting of ADRs at the same time.
出处
《解放军医药杂志》
CAS
2014年第2期78-80,共3页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
关键词
药品不良反应
监测
分析
Adverse drug reaction
Monitoring
Analysis
