摘要
目的 探讨霉酚酸酯 (MMF)联合小剂量环孢素A(CsA)和泼尼松 (Pred)治疗肾移植术后慢性排斥反应的临床效果。方法 对临床诊断为慢性排斥反应的 8例患者给予MMF 1.5～ 2 .0g/d、CsA 2～ 3mg·kg-1·d-1及Pred 10mg/d治疗。 结果 治疗后 4～ 9周 ,5例血清肌酐恢复正常 ,蛋白尿基本消失 ,2例肾功能改善 ,蛋白尿减轻 ,1例血清肌酐升高 ;治疗期间未发生急性排斥反应或肝功能损害 ;1例发生白细胞减少 ,1例出现腹泻 ,经处理后恢复正常。
Objectives To investigate the clinical efficacy of mycophenolate mofetil (MMF) combined with low dose CsA and prednisone (Pred) for treatment of chronic rejection in primary cadaveric renal recipients. Method A total of 8 renal recipients who were clinically diagnosed as having chronic rejection were given MMF 1.5 to 2.0 ?g/d, CsA 2 to 3?mg/kg per day and Pred 10?mg/d triimmunosuppressive agents . Results Blood creatinine was reduced to normal level and urine protein disappeared in 5 cases, blood creatinine and urine protein decreased obviously in 2 cases, and kidney function deteriorated in one case after this strategy for 4 to 9 weeks, respectively. No denova rejection episode or liver function damage occurred among these patients during treatment. Reduction of white blood cells in peripheral blood occurred in one case, but recovered after therapy.Conclusions MMF combined with low dose of CsA could bring out a considerable efficacy in reversing chronic rejection of renal recipients. This immunosuppresive stragety may be a useful routine in the treatment of chronic rejection.
出处
《中华器官移植杂志》
CAS
CSCD
北大核心
2001年第1期20-21,共2页
Chinese Journal of Organ Transplantation
