摘要
为了评价术苦芩颗粒对靶动物猪的安全性,选取60头健康的20日龄荣昌猪,随机分为4组,每组15头。各试验组分别以1倍(5 g/kg)、3倍(15 g/kg)、5倍(25 g/kg)推荐剂量的术苦芩颗粒连续经口灌胃给药14 d,观察临床症状、增重、血液学和组织病理学变化。结果显示,各组间的血液生理、生化指标无明显差异,组织无明显病理学病变,中剂量组仔猪日增重显著增加(P<0.05)。试验表明,术苦芩颗粒安全范围大,在仔猪体内耐受性高,以5倍推荐剂量灌胃14 d对靶动物猪安全。
In order to evaluate the safety of Zhukuqin granules on piglets, 60 healthy Rongchang piglets were randomly divided into 4 groups. Group 1, group 2 and group 3 was orally given Zhukuqin granules at dose of 5 g/kg, 15 g/kg and 25 g/kg for 14 days, respectively. Then clinical features, body weight, hemogram and histopathology were observed. The results showed that there was no significant difference in hemogram, hioehemical indexes between each group, and no change was found in histopathology. Body weight of piglets in group of medium dose increased significantly compared with that of blank group （P〈0.05）. The dose of 5 g/kg-25 g/kg of Zhukuqin granules is safe on piglets for continuously 14 days of intragastrie administration.
出处
《中兽医医药杂志》
2014年第1期5-8,共4页
Journal of Traditional Chinese Veterinary Medicine
基金
国家公益行(农业)科技专项金费资助(项目编号:20130304-05)
