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脂蛋白纳米药物传输系统研究进展 被引量:7

Advances in the research of lipoprotein-based nano scale drug delivery systems
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摘要 脂蛋白作为一种内源性纳米颗粒,具有生物相容性好、可彻底生物降解、无免疫原性、不被体内网状内皮系统识别而快速清除等优点,是一种极具前景的靶向药物载体。本文综述了近年来基于脂蛋白(乳糜微粒、极低密度脂蛋白、低密度脂蛋白和高密度脂蛋白)的纳米药物传输系统的最新研究进展。 Lipoproteins which are endogenous, biocompatible, completely biodegradable, and non-immunogenic, and can escape recognition and elimination by the reticuloendothelial system(RES)may well be studied as drug carriers. This article summarizes the advances in lipoprotein(chylomicrons, very low-density lipoprotein, low-density lipoprotein and high-density lipoprotein)-based nano scale drug delivery systems(LNDDS)in recent years.
出处 《中国药科大学学报》 CAS CSCD 北大核心 2014年第1期10-16,共7页 Journal of China Pharmaceutical University
基金 国家自然科学基金资助项目(No.81102398 81273469) 江苏省自然科学基金资助项目(No.BK2011624) 复旦大学药学院和智能化递药教育部重点实验室(复旦大学)开放课题资助项目(No.SDD2012-03) 中央高校基本科研业务费专项基金资助项目(No.JKVD2013011)~~
关键词 脂蛋白 纳米药物传输系统 靶向 进展 lipoprotein nano scale drug delivery system targeting advances
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