摘要
目的探讨G蛋白偶联受体37与儿童孤独症的关系。方法采用病例对照研究方法对120例孤独症患儿进行问卷调查及G蛋白偶联受体37(GPR37)含量测定。结果病例组患儿血清GPR37表达水平为(12.27±1.73),对照组为(5.35±1.66),差异有统计学意义(t=31.61,P<0.001)。孤独症严重程度与血清GPR37表达水平均呈正相关(r=0.87,P<0.001)。结论儿童孤独症的发病可能与血清中GPR37表达有关,GPR37的表达水平可能作为孤独症严重程度的指示因子。
Objective To evaluate the relationship between G protein-coupled receptors 37 and child autism. Meth- ods From January 2013 to November 2013,120 child autism outpatients and 120 healthy children were recruited from a hospital in Shenyang city. Children autistic disorder was investigated based on a questionnaire survey and the level of G protein-coupled receptors 37 was detected using enzyme-linked immunosorbent assay. Results The level of G protein- coupled receptors 37 in childhood autism group （ 12.27 ±1.73 ） was significantly higher than that in healthy group （5.35 ±1.66, t = 31.61, P 〈 0. 001 ）. There was a positive correlation between G protein-coupled receptors 37 and child- hood autism （ r =0. 87,P 〈 0. 001 ）. Conclusion G protein-coupled receptors 37 may influence the development of chil- dren autistic disorder, and it may be an indicator for children autistic disorder.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2014年第3期324-325,共2页
Chinese Journal of Public Health
基金
国家自然科学基金(81203004)
