摘要
目的探讨血清VILIP-1、IGF-1浓度与缺血性卒中患者认知障碍的关系。方法收集2012年6月1日～2012年12月31日在我院神经内科卒中单元住院治疗的急性脑梗死患者124例及健康志愿者96例。全面收集病例组及对照组的临床资料及数据，采用ELISA法测定血清VILIP-1、IGF-1浓度并比较各组血清VILIP-1、IGF-1浓度的差异，分析血清VILIP-1、IGF．1浓度与缺血性卒中后认知障碍的关系。结果血清IGF-1浓度认知功能障碍组（96．50±17．88ng／m1）明显低于认知功能正常组（114．62±14．01ng／m1），P〈0．01；血清VILIP-1浓度认知功能障碍组（669．69±103．84ng／m1）显著高于认知功能正常组（503．29±142．39ng/m1），P〈0．01。结论急性脑梗死患者高血清VILIP-1浓度、低血清IGF-l浓度，与卒中后认知障碍的发生存在相关性，且IGF-1可作为缺血性卒中后认知障碍的新的治疗靶点。
Objective To explore the relationship between the serum VILIP-1, IGF-1 concentration and cognitive impairment in patients with ischemic stroke. Methods 124 cases with acute ischemic stroke were admmitted in stroke unit ward of our hospital during June 1,2012 to December 31,2012.96 healthy volunteers were recruited as the healthy control. Clinical information and dates of case group and the control group were collected and analyzed. The concentrations of serum VILIP-1, IGF-1 were quantitatively determinated by ELISA. Compared respectively of the differences of serum VILIP-1, IGF- 1 concentrations between the cerebral infarction group and control group, the cognitive impairment group and normal cogni- tive function group,and to explore the relationship between serum VILIP-1, IGF-1 concentration and cognitive impairment after ischemic stroke. Results Compared with normal cognitive function group, the cognitive impairment patients had sig- nificantly higher VILIP-1 concentration [ （669.69 ± 103.84） pg/ml vs （503.29 ± 142.39） pg/ml;P 〈0.01 ] ,lower IGF- 1 concentration[ （96.50 ± 17.88） ng/ml vs （ 114.62 ± 14.01 ） ng/ml;P 〈0.01 ]. Conclusions There are correlation be- tween higher VILIP-1 serum concentrations,low serum concentrations of IGF-1 in patients with acute cerebral infarction and the occurrence of cognitive impairment after stroke.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2014年第2期121-124,共4页
Journal of Apoplexy and Nervous Diseases
关键词
缺血性卒中
认知障碍
视锥蛋白样蛋白-1
胰岛素样生长因子-1
Ischemic Stroke
Cognitive [mpairement
Visinin Like Protein-1 （ VILIP-1 ）
Insulin-like Growthfactor （ IGF-1 ）
