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对贝伐珠单抗在TNBC新辅助化疗应用中的思考 被引量:1

Application of bevacizumab in neoadjuvant chemotherapy of triple negative breast cancer
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摘要 从贝伐珠单抗特点及其在各种乳腺癌治疗中应用现状出发,探讨贝伐珠单抗应用于特定乳腺癌人群(如TNBC)或乳腺癌特定治疗阶段(如新辅助化疗)的获益可能性。 In this paper, with a review of the characteristics and application status of bevacizumab in various breast cancer therapies, we explored the potential benefits of bevacizumab used in specific subgroups of breast cancer (e.g. triple negative breast cancer) or breast cancer-specific treatment stage (e.g. neoadjuvant chemotherapy).
出处 《医学争鸣》 CAS 北大核心 2014年第1期41-43,共3页 Negative
基金 国家自然科学基金面上项目(81072179)
关键词 贝伐珠单抗 三阴性乳腺癌 新辅助化疗 bevacizumab triple negative breast cancer neoadjuvant chemotherapy
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  • 1Gray R, Bhattacharya S, Bowden C, et al. Independent review of E2100: a phase Ⅲ trial of bevacizumab plus paclitaxel versus paclitaxel in women with metastatic breast cancer[J]. J Clin Oncol, 2009, 27(30):4966-4972.
  • 2Rodgers M, Soares M, Epstein D, et al. Bevacizumab in combination with a taxane for the first-line treatment of HER2-negative metastatic breast cancer[J]. Health Technol Assess, 2011, 15(Suppl 1):1-12.
  • 3Schneider BP, Wang M, Radovich M, et al. Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100[J]. J Clin Oncol, 2008, 26(28):4672-4678.
  • 4Bear HD, Tang G, Rastogi P, et al. Bevacizumab added to neoadjuvant chemotherapy for breast cancer[J]. N Engl J Med, 2012, 366(4):310-320.
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  • 6徐兵河.HER2-乳腺癌,重新认识贝伐珠单抗价值[N].中国医学论坛报,2012-09-29.

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