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儿童伯基特淋巴瘤29例临床病理分析 被引量:11

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摘要 目的探讨儿童伯基特淋巴瘤( Burkitt' s lymphoma,BL)临床病理学特征及预后。方法根据WHO(2008)淋巴造血组织肿瘤分类标准,收集资料齐全的29例BL,运用免疫组化sP法观察CD3、CD20、CDl0、CD44、CD99、BCL-6、MUMl、BCL-2和Ki-67的表达,EBER原位杂交和荧光原位杂交( fluorescence in situ hybridization, FISH)技术检测c-myc基因重排情况。结果29例BL发病年龄1.5-13岁,中位年龄4岁,平均5.3岁,男女比例3.1:1。29例BL中CD20、CDl0和BCL-6均阳性,MUMl阳性5例,CD3、CD99、CD44和BcL-2均阴性,Ki-67增殖指数〉90%。6例EBER阳性,c—myc基因断裂29例。随访结果:单纯手术11例均死亡,术后18例行化疗,3例死亡,15例生存。结论根据形态学结合免疫表型和分子遗传学有助于BL的诊断,患者治疗依从性是影响生存率重要原因之一。
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2014年第2期216-218,共3页 Chinese Journal of Clinical and Experimental Pathology
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