摘要
目的探讨原发性肺印戒细胞癌(signet-ring cell carcinoma,SRCC)的临床病理特征及生物学特征。方法回顾性分析6例肺SRCC的临床病理资料,采用FISH技术检测其中2例肿瘤组织EML4-ALK基因融合情况,并复习相关文献。结果镜下见瘤细胞胞质内富含黏液,胞核偏于一侧呈印戒状。免疫表型:瘤细胞弥漫性表达TTF1和CK7,2例局部表达p63。2例瘤组织EML4-ALK融合基因阳性。患者容易发生淋巴结和远处转移。结论原发性肺SRCC有特异性组织学特点、免疫表型和基因改变,提示其可能为腺癌的一种亚型,与其他腺癌相比预后差。
Purpose To investigate the clinical pathology and biologic characteristics of primary lung signet-ring cell carcinoma （SRCC）. Methods The clinical data and histopathological features of 6 cases of primary lung SRCC were reviewed. FISH was per- formed on 2 cases using a break-apart probe for the ALK gene, and the related literatures were reviewed. Results The tumour cells were rich in mucin, which pushed against the cell nucleus creating a signet-ring cell appearance under light microscope. The immuno- histochemieal stains showed that 6 tumors were diffusely immunopositive for TYF-1 and CKT. Two tumors were also focal immunoreac- tive for p63. The positive EMIA-ALK rearrangement was obtained in two tumors by FISH. Lymph nodes and distance metastasis were more frequently found in SRCC. Conclusions The characteristic histology, immunoprofile, and frequent ALK translocation may sug- gest that SRCC forms a histological/molecular subgroup of adenocarcinoma. It carries a worse prognosis compared to the other adenoear- cinomas.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2014年第2期163-165,170,共4页
Chinese Journal of Clinical and Experimental Pathology
基金
全军临床高新技术重大项目(2010gxjs027)
