摘要
目的探讨HIV感染者/AIDS患者(HIV/AIDS)近期预后的危险因素。方法回顾性分析164例HIV/AIDS患者的基线(性别、年龄、婚姻状况、传播途径、WHO临床分期和CD4+T淋巴细胞)及随访资料(是否开始HAART、预后状态和生存时间),观察期为48周,用Kaplan-Meier法计算平均生存期,生存函数曲线的比较用Log Rank检验。结果 164例HIV/AIDS患者在随访期内生存105例(64.02%),死亡59例(35.98%),其中24周内累计死亡55例(93.22%),死亡原因均为AIDS相关性疾病。本研究中年龄≤50岁组的平均生存期(269d)高于年龄>50岁组(209d)(P<0.05);男性组的平均生存期(226d)小于女性组(303d)(P<0.05);WHO临床分期I,II和III期组的平均生存期(330d)明显高于WHO临床分期Ⅳ期组(172d)(P<0.05);基线CD4+>50个/mm3组的平均生存期(297d)也高于基线CD4+≤50个/mm3组(205d)(P<0.05);未开始HAART组平均生存期只有48d,明显低于已接受HAART组(336d)(P<0.05);性传播者的平均生存期(253d)和血液传播者(274d)相近(P>0.05)。结论确诊HIV/AIDS时的年龄>50岁、男性、WHO临床IV期、基线CD4+≤50个/mm3和未开始HAART是影响本地区HIV/AIDS患者近期预后的危险因素。
Objective To investigate risk factors of prognosis for HIV-positive individuals and AIDS patients. Methods The general and follow-up data of 164 cases of HIV-infected individuals and AIDS patients（HIV/AIDS） were included for retrospective analysis. The survey last for 48 weeks. The average survival time was calculat- ed by Kaplan Meier method. The survival function curve was compared with the Log Rank test. Results 105 eases（ 64.02% ） survived and 59 cases（ 35.98% ） died during the follow-up period. The death rate reached 93.22% （55/59） during the first 24 weeks. The cause of death was AIDS related illnesses. The average sur- vival time of the younger group （ 〈 50 years of age） was 269 days, which was longer than 209 days of the 〉 50 year-old group（ P 〈 0. 05 ）. The average survival time of male group（226d） was less than that of female group（303d） , （P 〈0.05）. The average survival time of WHO clinical stage Ⅰ, Ⅱ and Ⅲ group（330d） was significantly longer than that of WHO clinical stage IV （172d） （ P 〈 0. 05 ）. The average survival time of the group whose baseline CD4^＋ cells was of above 50/mma （297d） was longer than that of the group whose base- line CD4^＋ was below 50/mm^3 （205d）（P 〈 0. 05 ）. The average survival time of group who had not started HAART was 48d, however, that of patient who received HAART reached up to 336d（ P 〈 0.05 ）. The average survival time of patients transmitted by sex activities （253d） was similar to those infected by blood samples （274d） , （P 〉 0.05 ）. Conclusion The prognosis risk factors in recent period for HIV/AIDS patients are age above 50 years old, WHO clinical stage IV, baseline CD4^＋ ceils less than 50/mm^3 and non-HAART.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2014年第3期279-281,共3页
The Chinese Journal of Dermatovenereology
基金
柳州市科学研究与技术开发计划课题(编号2013J030401)
广西卫生厅计划课题(编号Z2013645)
关键词
人类免疫缺陷病毒
获得性免疫缺陷综合征
高效抗逆转录病毒治疗
预后
Human immunodeficiency virus （HIV）
Acquired immune deficiency syndrome（AIDS）
Highly active an-ti-retroviral therapy（HAART）
Prognosis
