摘要
目的：应用可视化血液流变性检测仪（MC-FAN）并结合血小板功能指标的检测，观察急性冠脉综合征（ACS）介入术后患者血液流变性的变化特点，并探讨患者血液流变性可视化结果与血小板功能指标的相关性。方法：纳入74例ACS介入术后1～3年的患者，21例健康者为健康对照组，应用MC—FAN检测2组人群的血液通过模拟人体毛细血管的时间（MC—FANTT）和比较不同时段的结果，同时检测血小板聚集性、血小板黏附性、血小板P-选择素、血小板衍生生长因子BB和血管假性血友病因子指标，观察ACS介入术后患者的MC—FAN结果与血小板功能的相关性。结果：与健康对照组相比，ACS介入术后患者的血流MC-FAN TT延长（P〈0．01），红细胞变形能力减弱，白细胞附壁及血小板的黏附、聚集相对增多；ACS介入术后患者的血小板最大聚集率、血小板黏附率、血小板P-选择素水平及血小板衍生生长因子BB水平均高于健康对照组（P〈0．01）；2组间血管假性血友病因子差异无统计学意义（P〉0．05）。组内相关性分析显示：MC—FANTT与血小板功能存在相关性，其中10μL MC—FANTF和30μMC—FANTT与P-选择素呈正相关（r=0．601，P〈0．01；r=0．334，P〈0．01）；60μL MC-FANTT与血小板最大聚集率呈正相关（r=0．527，P〈0．01）；100μL MC—FANTT与血小板黏附率呈正相关（r=0．815，P〈0．05）。结论：ACS介入术后患者的可视化血液流变性及血小板功能异常，MC—FANTT与血小板功能存在相关性，MC—FAN检测仪可客观地评价介入术后患者血液流动的状态。
AIM： To intuitionally observe the characteristics of blood rheology in the patients with acute coro- nary syndrome （ACS） after pereutaneous coronary intervention （PCI） for 1 year to 3 years by micro-channel array flow an- alyzer （MC-FAN） combined with other platelet function indexes, and to explore the correlations between the test results of MC-FAN and platelet function. METHODS： This study brought 74 patients with ACS after PCI for 1 year to 3 years into test group, and 21 healthy subjects were enrolled as normal group. The levels of platelet aggregation test （PAgT）, platelet adhesiveness test （PAdT） , P-selectin, platelet-derived growth factor BB （PDGF-BB） and yon Willebrand factor （vWF） were detected. MC-FAN HR300 was used to detect the transiting time （ MC-FAN TT） of the blood passing through the model body capillaries. The differences of the test results between the 2 groups were compared, and the correlations be- tween the results of MC-FAN and platelet function in the patients with ACS after PCI were also explored. RESULTS ： Com- pared with normal group, the MC-FAN TT in test group was prolonged （P 〈 0.01 ）, the ability of erythroeyte deformation was weakened, and the leukocyte attaching the vascular wall and platelet adhesion and aggregation relatively increased. The levels of PAgT, PAdT, P-selectin and PDGF-BB in test group were all higher than those in normal group （ P 〈 0.01 ）. No difference of vWF between the 2 groups was observed. The intergroup correlation analysis showed that there were correla- tions between MC-FAN TT and platelet function, in which 10 μL MC-FAN TT and 30 μL MC-FAN TT had the most signifi- cant correlation with P-selectin （r =0. 601, P 〈0.01 ; r =0. 334, P 〈0.01 ）, 60 μL MC-FAN TT had the most significant correlation with PAgT （r =0. 527, P 〈0.01 ）, and 100 μL MC-FAN TT had the most significant correlation with PAdT （r =0. 815, P 〈0.05）. CONCLUSION： The visualization of hemorrheologic changes and platelet function in the pa- tients with ACS after PCI are abnormal. There are correlations between MC-FAN TT and platelet function. The results of MC-FAN can objectively evaluate the blood rheology of the patients, and provide the reference for clinical treatment.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2014年第2期214-219,共6页
Chinese Journal of Pathophysiology
基金
中日合作课题研究项目(No.XYW01-20100526)
"重大新药创制"科技重大专项基金项目(No.2009ZX09502-031)
