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贫血患者1528例骨髓细胞形态学检查结果分析 被引量:14

Retrospective analysis of bone marrow morphological examination results in i 528 anemia patients
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摘要 目的探讨骨髓细胞形态学检查在寻找贫血病因中的作用,了解1998至2002年和2008至2012年2个5年间贫血疾病谱的变化。方法回顾性研究。对1998至2002年和2008至2012年2个5年间1528例上海交通大学附属第一人民医院初诊为贫血待查患者的骨髓穿刺标本进行瑞氏染色和细胞化学染色,显微镜下观察细胞形态和染色结果,并结合临床资料统计分析1998至2002年和2008至2012年2个5年间疾病种类变化。结果确诊为造血和淋巴组织疾病患者1139例(74.54%),其中以缺铁性贫血、白血病和巨幼细胞性贫血为3种主要类型致贫血的病因。感染性贫血骨髓象及描述性诊断骨髓象389例(25.46%)。贫血疾病谱发生了明显变化:缺铁性贫血由(30.34%,139/458)降至(18.69%,200/1070),白血病由(13.31%,61/458)增长至(21.77%,233/1070),骨髓描述性诊断比例由(15.72%,72/458)增长到(21.86%,234/1070)。结论骨髓细胞形态学检查是查找贫血病因的重要手段,有助于指导针对病因的有效治疗。(中华检验医学杂右,2014,37:115—118) Objective Retrospective investigate the significant application of bone marrow (BM) morphology in exploring the causes of anemia, and observed the changes of anemia disease spectrum in the past 10 years. Methods BM smears of 1 528 anemia patients from Shanghai Jiao Tong University Affiliated Shanghai First People's Hospital were stained with Wright's staining and cytochemical staining and observed with microscope. Combined with relevant clinical data, we analyzed the changes of disease types from 1998 to 2002 and from 2008 to 2012. Results 1 139 cases (74. 54% ) were diagnosed with hematopoietic and lymphatic system diseases. Iron-deficiency anemia, megaloblastie anemia and leukemia were the three main causes of anemia. The BM morphology of 389 patients displayed infection anemia or descriptive diagnosis. Anemia disease spectrum changed a lot, iron-deficiency anemia decreased from 30. 34% (139/458) to 18.69% (200/1 070) , leukemia increased from 13.31% (61/458) to 21.77% (233/1 070) , descriptive diagnosis of BM increased from 15.72% (72/458) to 21.86% ( 234/1 070) . Conclusion BM examination is critical for finding the cause of anemia, which contributes to effective treatment. ( Chin J Lab Med,2014,37:115-118)
出处 《中华检验医学杂志》 CAS CSCD 北大核心 2014年第2期115-118,共4页 Chinese Journal of Laboratory Medicine
关键词 贫血 骨髓检查 细胞诊断学 回顾性研究 Anemia Bone marrow examination Cytodiagnosis Retrospective studies
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