摘要
目的探讨骨肉瘤肺转移致自发性气胸患者的生存情况及影响预后的因素。方法回顾性分析14例发生自发性气胸和40例同期未发生自发性气胸的骨肉瘤肺转移患者的临床资料，生存分析采用Kaplan-Meier法，多因素分析用Cox比例风险模型。结果54例骨肉瘤肺转移患者均获随访。14例自发性气胸患者的中位无进展生存时间（PFS）为2个月，中位总生存时间（OS）为11个月，2年生存率为14．3％（2／14），而未发生自发性气胸的40例骨肉瘤肺转移患者分别为2个月、16个月和35．O％（14／40），两组OS的差异有统计学意义（P〈0．05）。气胸发生率及PFS与化疗情况无关（P〉0．05）。肺转移灶数目和自发性气胸是影响骨肉瘤肺转移患者Os的独立因素（HR=0．34，95％CI：0．15～0．79，P=0．01；HR=0．38，95％CI：0．16~0．87，P=0．02）。结论自发性气胸的发生与骨肉瘤肺转移的不良预后有关。
Objective To investigate the survival and prognosis related factors of osteosarcoma patients with lung metastasis suffering spontaneous pneumothorax. Methods The data of 14 metastatic osteosarcoma patients with spontaneous pneumothorax and 40 osteosarcoma patients without spontaneous pneumothorax were reviewed. Survival analysis was performed by Kaplan-Meier method. A Cox regression model was utilized to analyze risk factors affecting the prognosis of metastatic osteosarcoma. Results Fifty-four meta- static osteosarcoma patients were all followed up. The median progression free survival（PFS） and median overall survival（OS） were 2 months and I I months, respectively, and the 2-year survival rate was 14. 3%. In 40 patients without spontaneous pneumothorax, those data were 2 months, 16 months and 35.0%. The difference of OS between patients with/without spontaneous pneumothorax was signifi- cant （P〈O. 05）. Cox regression model revealed that number of lung metastatic lesions and spontaneous pneumothorax were indepengdent factors affecting OS（HR=0. 34,95%CI：0. 15-0. 79,P=0. 01 ;HR=0. 38,95%CI：0. 16-0. 87,P=0.02）. No correlation was found be- tween the incidence of spontaneous pneumothorax, PFS and chemotherapy. Conclusion In osteosarcoma patients with lung metastasis, spontaneous pneumothorax is associated with poor prognosis compared with those without this complication.
出处
《临床肿瘤学杂志》
CAS
2014年第1期65-68,共4页
Chinese Clinical Oncology
关键词
骨肉瘤
肺转移
自发性气胸
Osteosarcoma
Lung metastasis
Spontaneous pneumothorax
