摘要
肝动脉化疗栓塞术(TACE)已成为不能手术切除的中晚期肝细胞癌的首选疗法。树突状细胞(dendritic cells,DC)是目前已知功能最强大的专职抗原呈递细胞,在抗肿瘤免疫中起到关键作用。随着肿瘤介入及免疫治疗的发展,TACE联合DC治疗肝癌逐渐成为研究热点,研究证实两者联合治疗肝癌疗效显著,且对机体免疫功能有正向调节作用,展现了良好的前景。本文就TACE、DC及TACE联合DC治疗肝癌对机体免疫功能影响做一综述。
Transcatheter arterial chemoembolization （TACE） has become the treatment of first choice for inoperable advanced hepatocellular carcinoma. Dendritic cell （DC） is now known as the most powerful specific antigen- presenting cell and it plays a very important role in anti- tumor immunity. With the development of interventional therapy and immune therapy, TACE combined with DC has become the hot topic in the research of liver cancer. Recent researches have indicated that the combination use of TACE and DC has remarkable curative effect and it carries positive influence on human＇s immune function, indicating that this technique has certain promising prospects. This paper aims to make a comprehensive review, focusing on the changes of immune function in patients with liver cancer after TACE, DC and TACE combined with DC treatment. （J Intervent Radiol, 2014, 23： 181-184）
出处
《介入放射学杂志》
CSCD
北大核心
2014年第2期181-184,共4页
Journal of Interventional Radiology
基金
大连市科技局项目(2010E15SF180)
关键词
肝动脉化疗栓塞术
树突状细胞
肝癌
免疫功能
研究进展
transeatheter arterial chemoembolization
dendritic cell
liver cancer
immune function
research progress
