摘要
研究了以魔芋葡甘聚糖和明胶为壁材,以盐酸硫胺素(VB1)、核黄素(VB2)、盐酸吡哆醇(VB6)、叶酸、烟酰胺的混合物为芯材,采用冷冻干燥工艺,制备水溶性复合维生素微胶囊.首先通过单因素实验(考察了壁材浓度、魔芋葡甘聚糖/明胶、壁材/芯材等),得出较佳的工艺条件为:壁材浓度为2%,魔芋葡甘聚糖(KGM)/明胶(Gel)为1∶1,壁材/芯材为10∶1.然后应用Design-Expert.V8.0.6软件进行响应面分析,结果表明:3个因素都对微胶囊包埋率有显著的影响,且实验得出的真实最佳工艺参数为:壁材浓度为2.13%,KGM/Gel为1.32∶1,壁材/芯材为10.67∶1,在此条件下得到的微胶囊包埋率为78.82%.
The freeze drying process was used to prepare water soluble compound vitamin microcapsules with konjac glucomannan and gelatin as the wall material and the mixture of thiamine hydrochloride （VB1）, riboflavin （VB2）, pyridoxine hydrochloride （VBG）, folic acid and nicotinamide as the core materi al. First, single factor experiments were conducted, and the desirable polytechnic conditions were identi fled as 2% for wall material concentration, 1 ： 1 for KGM/gelatin ratio and 10 ： 1 for wall/core material ratio. Then, response surface analysis （RSA） was made with the Design Expert. VS. 0.6 software, and the results showed that all the three factors had significant impacts on the embedding rate of microcap sules, and the results of response surface analysis showed that the real optimal parameters derived from the experiments were wall material concentration 2.13%, KGM/Gel ratio 1.32 ： 1 and wall/core malerial ralio 10.67 ： 1. Under these conditions, an embedding rate of microcapsules of 78.82% was obtained.
出处
《西南大学学报（自然科学版）》
CAS
CSCD
北大核心
2014年第2期164-170,共7页
Journal of Southwest University(Natural Science Edition)
基金
国家自然科学基金项目(31271837
31071518)
教育部高等学校博士学科点专项科研基金联合资助(20113515110010)
科技部专项研究经费(2012GA7200022)
福建省高校产学研重大专项(2013N5003)
福建省自然科学基金(2011J0101)
福建省教育厅科技计划项目(JA13439
JA13440)
