摘要
近年来刺激响应性聚合物胶束作为一种极有潜力的纳米药物载体得到了越来越广泛的关注,也是高分子领域研究的热点。本文概述了载药高分子胶束的发展特点和应用面临的主要困境,主要总结了温度敏感性高分子及其胶束的类别和特点,并重点阐述了热敏性可降解高分子及其胶束药物载体的最新研究进展,探讨了高分子胶束药物载体进入临床应用面临的挑战和解决问题的一些简单思路,相信多功能化的稳定的温敏性可降解载药高分子胶束系统在解决临床治疗问题上前景光明。
In recent years growing attention has been given to development of stimuli-responsive polymeric micelles as a potential nano drug delivery system and hot research field in polymer. In this review,the characteristics and main problems in clinic application on polymeric micelles for drug delivery are briefly introduced. The classification and features of the thermosensitive polymers and their micelles are summarized. The recent progress on degradable and thermosensitive polymers and their micelles as drug carriers are expounded in detail. The challenges and opportunities of the polymeric micelles as drug carriers for clinic application have been discussed. We believe that multi functional drug delivery systems with good stability based on degradable and thermosensitive polymeric micelles will eventually be generated to achieve clinic treatment.
出处
《高分子通报》
CAS
CSCD
北大核心
2014年第2期60-67,共8页
Polymer Bulletin
基金
国家自然科学基金(21074100,21174109)
关键词
聚合物胶束
温敏性
可降解
药物载体
胶束制备
Key words.. Polymeric micelles
Thermosensitivity
Degradable
Drug delivery
Preparation of mieelles
