摘要
为比较速康解毒口服液以口服和肌肉注射2种方式给药后大鼠血浆内解毒水剂各组分的浓度,探明速康解毒口服液在体内的动力学特征,试验将28只试验大鼠随机分为7组,以口服、肌肉注射2种方式给药,用紫外可见分光光度法测定给药后不同时间各组分的血药浓度,计算解毒水剂各组分的药代动力学参数。结果表明解毒水剂各组分在大鼠体内的血药浓度—时间过程可用吸收的二室模型来描述,口服给药后各组分的最大血药浓度分别为正磷酸钠8039.455μg/mL,酵母甘露聚糖129.932μg/mL,硫酸镁3358.328μg/mL,L-鼠李糖2296.330μg/mL。正磷酸钠、硫酸镁、酵母甘露聚糖、L-鼠李糖口服后的Tp分别为1.2816、1.4201、1.1337、0.9469h;肌肉注射Tp分别为1.2856、1.4684、1.1079、1.1671h。试验结果表明速康解毒口服液各组分给药后很快进入血液,口服和肌肉注射给药差别不大,但口服给药作用时间相对较长,给药方式较肌肉注射方便。
In order to compare the concentration of each component of Sukang detoxification oral liquid in rat plasma after administrated by oral and intramuscular, and ascertain pharmacokinetic characteristics of Sukang detoxification oral liquid in tri- als rats, 28 rats were randomly divided into seven groups, using UV spectrophotometry to measure plasma concentration of each component at different times after administrated by oral and intramuscular, calculated pharmaeokinetics parameters of va rious components of detoxification agent. The results showed that plasma concentration-time process of each component of detoxifieation agent in rats could be described as two-compartment model tools with absorption. After oral administration the maximum plasma concentrations of each component were sodium 8039. 455 μg/mL, yeast mannan 129. 932 μg/mL, magnesium3358. 328μg/mL, rhamnose 2296. 330μg/mL. Tp （h） by oral administration of sodium, sulfate, yeast mannan, L-rhamnose were 1. 2816,1. 4201,1. 1337,0. 9469 h;by intramuscular administration they were 1. 2856,1. 4684,1. 1079,1. 1671 h. Experi- mental studies had shown that each component of Sukang detoxification oral liquid was quickly absorbed into the blood after ad- ministration, there was little difference between oral and intramuscular administrations, but oral administration had longfunc- tion and more convenient on administration than intramuscular.
出处
《中国畜牧兽医》
CAS
北大核心
2014年第2期129-135,共7页
China Animal Husbandry & Veterinary Medicine
基金
中央级公益性科研院所基本科研业务费专项资金(1610322012001)
国家高新技术研究发展计划(863计划)(2011AA10A214)
西藏横向委托项目(2011-2013)
关键词
速康解毒口服液
紫外分光光度法
药代动力学
Sukang detoxification oral liquid
UV spectrophotometry
pharmacokinetics
