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原发性肝癌组织中OPN、GP73的表达变化及意义 被引量：5

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摘要 目的观察原发性肝癌组织中骨桥蛋白(OPN)和高尔基体糖蛋白-73(GP73)的表达变化并探讨其意义。方法采用免疫组化SP法检测45例肝癌组织(肝癌组)和15例正常肝组织(对照组)中的OPN与GP73,观察不同临床病理特征肝癌患者肝脏组织中两者的表达变化。结果肝癌组OPN表达阳性率为71.1%(32/45),GP73表达阳性率为91.1%(41/45),高于对照组的15%(3/20)、0%(0/20),P均<0.05。OPN和GP73的表达在不同淋巴结转移情况、Edmondson分级和TNM分期者中差异有统计学意义(P均<0.05),且两者在肝癌组织中的表达呈正相关关系(r=0.569,P<0.01)。结论肝癌组织中OPN和GP73的表达高于正常肝组织,二者可能与肝癌的发生发展有关。
作者 高万军 祁楠
机构地区 齐鲁石化医院集团中心医院 解放军总医院第一附属医院
出处 《山东医药》 CAS 2014年第2期60-61,共2页 Shandong Medical Journal
关键词 肝癌 骨桥蛋白 高尔基体糖蛋白
分类号 R735.7 [医药卫生—肿瘤]
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参考文献14

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同被引文献70

  • 1陈晓香,孙萍,姚晓宾.鳞状细胞癌抗原检测在原发性肝癌诊断中的意义[J].中国实用医刊,2010,37(14):69-70. 被引量：2
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引证文献5

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山东医药
2014年 第2期

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