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星形细胞上调基因1（AEG -1）在肝细胞癌中的研究进展 被引量：4

The biology function of Astrocyte elevated gene-1（AEG-1）in hepatocellular carcinoma
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摘要 星形细胞上调基因1（Astrosyte elevated gene 1， AEG-1）自2002年作为艾滋病病毒诱导的新型癌基因被发现以来，有关其在细胞中的生物学功能及人类肿瘤中的作用一直是研究热点。本文详细阐述了近年来发现AEG-1的重要生物学功能以及它的一些生化特性，包括一些氨基酸序列及核定位信号通路，并总结了AEG-1在肝细胞癌（ Hepatocellular carcinoma ，HCC）中的相关研究进展。认识到AEG-1发挥生物学效应的分子机制及作用的具体信号通路，能够帮助我们对AEG-1本身及其在HCC中的重要作用有更深入的了解。 Since initial identification of astrocyte elevated gene -1 （ AEG-1 ） as a HIV-1-inducible novel oncogene in 2002 ,it has emerged as an important oncogene providing a valuable prognostic marker in pa-tients with various cancers.The present review discusses AEG -1 structure,function and localization.Further-more,we summarize the potential role of AEG -1 in the progression of hepatocellular carcinoma （HCC）.This re-view can help us better understand the molecular mechanism in hepatocarcinogenesis .
作者 李聪(综述) 龙江(综述) 生守鹏(综述) 孙玉(综述) 张洪海(综述) 李建军(综述) 郑加生(审校)
机构地区 首都医科大学附属北京佑安医院肿瘤肝胆介入微创治疗中心
出处 《实用肿瘤学杂志》 CAS 2014年第1期61-65,共5页 Practical Oncology Journal
关键词 星形细胞上调基因1 核定位信号 肝细胞癌 乙型肝炎 Astrosyte ELEVATED GENE 1 NSL Hepatocellular carcinoma Hepatitis B virus
分类号 R730.231 [医药卫生—肿瘤]
  • 相关文献

参考文献32

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二级参考文献11

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共引文献13

同被引文献56

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实用肿瘤学杂志
2014年 第1期

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