摘要
目的:应用Meta分析评价新辅助化疗在局部晚期胃癌综合治疗中的价值。方法:利用计算机检索PubMed、Embase、CochraneLibrary、中国生物医学文献数据库(China Biology Medicinedisc,CBMdisc)、中国知网(National Knowledge Infrastructure,CNKI)、中国期刊全文数据库(China Academic Journals Full-text Database,cJFD)、万方数据资源系统(Wanfang Data)、中国学术会议文献数据库和中国肿瘤防治数据库等。按照文献纳入标准和排除标准选择临床随机对照试验(randomized controlled trial,RCT)文献,评价文献质量,并提取资料,应用RevMan5.0软件进行Meta分析。结果:最终纳入8篇RCT文献,共1260例患者。新辅助化疗联合手术治疗组与单纯手术组的手术切除率[优势比(oddsratio,OR)为1.04,95%可信区间(confidence interval,CI)为0.76~1.43,P=0.79]、根治性手术切除率(OR为1.02,95%C7为0.57~1.83,P:0.94)和围手术期死亡率(OR为1.06,95%CI为0.56~2.00,P=0.86)差异均无统计学意义。两组的1年生存率差异无统计学意义(OR为1.05,95%CI为0.79~1.41,P=0.72),但新辅助化疗联合手术治疗组的2年生存率(飧为1.33,95%CI:1.03~1.72,P=0.03)和3年生存率(0R为1.61,95%CI为1.23~2.09,P=0.0005)均高于单纯手术组。结论:局部晚期胃癌新辅助化疗不增加手术切除率和手术风险,可提高远期生存率。
Objective:To evaluate the efficacy of neoadjuvant chemotherapy(NC)for locally advanced gastric cancer by Meta-analysis.Methods:A computer-based online search of PubMed,Embase,Cochrane Library,China Biology Medicine disc(CBMdisc),National Knowledge Infrastructure(CNKI),China Academic Journals Full-text Database(CJFD),Wanfang Data,China Conference Paper Database(CCPD)and China Cancer Database was performed.In accordance with the inclusion and exclusion criteria,the randomized controlled trials(RCTs)were selected.After evaluating the quality of the included studies and extracting the data,a Meta-analysis was perfomed by using RevMan 5.0 software.Results:A total of 8 RCTs including 1260 patients were included in this Meta-analysis.The resection rate[odds ratio(OR):1.04,95%confidence interval(C/):0.76-1.43;P=0.79],radical resection rate(OR:1.02,95%CI:0.57-1.83;P=0.94)and perioperative mortality(OR:1.06,95%CI:0.56-2.00;P=0.86)beween the neoadjuvant chemotherapy combined with surgical operation group and surgical operation alone group were not statistically different.The difference in one-year survival rate was not statistically significant(OR:1.05,95%CI:0.79-1.41;P=0.72)between the two groups,but the 2-year(OR:1.33,95%CI:1.03-1.72;P=0.03)and 3-year(OR:1.61,95%CI:1.23-2.09;P=0.0005)survival rates of the neoadjuvant chemotherapy combined with surgical operation group were higher than those of the surgical operation alone group.Conclusion:Neoadjuvant chemotherapy for locally advanced gastric cancer may not increase the resection rate and the operation risk,and it can improve the long-term survival rate.
作者
庞丽娜
王峰
何炜
李向柯
周然
曹蕾
樊青霞
PANG Li-na;WANG Feng;HE Wei;LI Xiang-ke;ZHOU Ran;CAO Lei;FAN Qing-xia(Department of Medical Oncology,First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China)
出处
《肿瘤》
CAS
CSCD
北大核心
2014年第2期169-174,共6页
Tumor
关键词
胃肿瘤
局部晚期
新辅助化疗
META分析
Stomach neoplasms
Locally advanced
Neoadjuvant chemotherapy
Meta analysis
