摘要
目的探讨新疆汉族和维吾尔族人群阿尔茨海默病（AD）患病的危险因素。方法对新疆地区汉族和维吾尔族≥50岁常住人口进行流行病学调查，采用中文简易精神状态量表（MMSE）进行可疑AD初筛，MMSE分值低于划界分者再用Hachinski（HIS）缺血指数量表和日常生活能力量表（ADL）进一步细查，最后根据美国国立神经病语言障碍卒中研究所AD及相关疾病协会（NINCDS／ADRDA）标准诊断出很可能AD患者。采用病例对照研究方法按与病例组民族相同、年龄相同或相近的原则以1：2比例随机选出对照组，分别对不同种族人群AD患病相关因素进行单因素及多因素Logistic回归分析。结果汉族很可能AD组109例，对照组218例；维吾尔族很可能AD组127例，对照组254例。Logistic回归分析结果显示在汉族人群中，女性、血清总胆固醇（Tc）升高者及低密度脂蛋白胆固醇（LDL-C）升高者患AD的风险分别是男性、非TC升高者及非LDL—C升高者的3．078、1．369和2．794倍（OR=3．078、1．369、2．794，均P〈0．05）；在维吾尔族人群中，女性、有脑外伤史、三酰甘油（TG）升高及TC升高者患AD的风险分别是男性、无脑外伤史者、非TG升高者及非TC升高者的3．279、3．447、1．407和1．746倍（OR=3．279、3．447、1．407、1．746，均P〈0．05）结论女性、高胆固醇血症是汉族和维吾尔族人群患AD共同的危险因素；在汉族人群中，高LDL-c亦是AD的危险因素，而在维吾尔族人群中，脑外伤史和高TG亦是AD的危险因素。
Objective To investigate the related factors for Alzheimer＇s disease（AD） in Han versus Uygur populations in Uygur Autonomous Region. Methods A case-control study was conducted. Firstly, people over 50 years old were involved in epidemiology inquisition in Xinjiang Uygur Autonomous Region. Then we screened for dementia by MMSE and scrutinized the person who got the score of MMSE for illiteracy（≤17）, elementary school（〈20）, middle school and above it（〈 24） by Hachinski Ischemic Score（HIS） and activity of daily living scale（ADL）. Finally, AD cases were diagnosed by standard of the national institute of neurologic, communicative disorders and stroke and AD-related disorders association （NINCDS-ADRDA）, and controls were selected based on age roughly. Univariate and multivariate analysis of related factors for AD in the two populations were conducted by using logistic regression mode. Results There were 109 AD cases and 218 controls in Han population and 127 AD cases and 254 controls in Uygur population. Logistic regression analysis showed that the risk for AD in Han population was increased by 3. 078, 1. 369 and 2. 794 folds respectively in women, people with high level of serum total cholesterol and people with low-density lipoprotein cholesterol as compared with men, people with normal level of serum total cholesterol and people with low-density lipoprotein cholesterol（OR = 3. 078, 1. 369 and 2. 794, respectively, all P~ 0.05）~ and the risk for AD in Uygur population was increased by 3. 279, 3. 447, 1. 407 and 1. 746 folds respectively in women, people with brain trauma history, and people with high level of serumtriglyceride and total cholesterol as compared with men, people without brain trauma history and with normal level of serum triglyceride and total cholesterol（OR=3. 279, 3. 447, 1. 407 and 1. 746, all P〈0.05）. Conclusions The study demonstrates that female and high total cholesterol are the risk factors for AD in both of Han and Uygur populations. High level of low-density lipoprotein cholesterol is one of the risk factors for AD in Han population, and brain trauma history and high level of serum triglyceride are risk factors for AD in Uygur population.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2014年第2期205-209,共5页
Chinese Journal of Geriatrics
关键词
阿尔茨海默病
汉族
维吾尔族
Alzheimer disease
Han nationality
Uygur nationality
