摘要
目的分析老年糖尿病患者药物性低血糖的相关危险因素，为临床防治奠定基础。方法收集本院2011年1月至2013年10月收治的药物性低血糖老年糖尿病患者（观察组）78例的临床资料及同期老年糖尿病无低血糖事件发生患者（对照组）256例的临床资料，对两组患者的相关资料进行对比分析，筛选出潜在的引发药物性低血糖的危险因素。结果观察组病情稳定率为38．5％（30／78），明显低于对照组52．7％（135／256），差异有统计学意义（X2=4．872，P=0．028）。观察组饮食控制治疗9例（11．5％），胰岛素治疗28例（35．9％），磺胺药物治疗41例（52．6％），对照组分别为89例（34．8％）、89例（34．8％）和78例（30．4％）；观察组采用饮食控制治疗明显低于对照组（X2=15．557，P〈O．001），磺胺药物治疗明显高于对照组（X2=12．726，P〈O．001），胰岛素治疗两组差异无统计学意义（X2=0．034，P=0．854）。观察组年龄明显高于对照组（t=2．494，P=0．007），体质指数（产4．334，P〈O．001）和糖化血红蛋白（t=7．251，P〈0．001）明显低于对照组；空腹血糖（t=1．010，P=0．157）和血肌酐（t=0．297，P=0．383）比较，差异无统计学意义；观察组糖尿病病程明显长于对照组，差异有统计学意义（t=2．579，P=0．005）。结论老年糖尿病患者发生药物性低血糖与年龄偏大、糖尿病病程长、体质指数低、糖化血红蛋白低、血糖控制效果差和磺胺药物使用高等因素相关。
Objective To analyze the risk factors for drug-induced hypoglycemia in elderly diabetic patients, and to provide the basis for clinical prevention and treatment. Methods 78 cases with drug-induced hypoglycemia in elderly diabetic patients （observation group） and 256 elderly diabetic patients without drug-induced hypoglycemia （control group） were included, and the relative factors for drug-induced hypoglycemia were analyzed between the two groups. Results The stable rate of patient＇s condition was lower in observation group than in control group [38.5 % （30/78） vs. 52.7%（135/256） , X2 =4. 872, P〈0.05]. There were 9 cases （11.5%）, with alimentary control, 28 cases （35.9%） treated with insulin and 41 cases （52.6%） treated with sulfonamide in observation group,and 89 cases （35.9%） with alimentary control, 89 cases （34.8%） treated with insulin and 78 cases （30.4%） treated with sulfonamide in control group. The alimentary control was lower in observation group than in control group（X2 = 15. 557, P〈0.001）. There was no difference in successful rate of insulin treatment between the two groups （X2 = 0. 034, P〉0.05）. The successful rate of sulfonamide treatment was higher in observation group than in control group（X2 = 12. 726, P〈 0. 001）. The age was older in observation group than in control group（t=2. 494, P〈0.01）. The body mass indexes and glycosylated hemoglobin level were lower in observation group than in control group（t=4. 334 and 7. 251, both P〈0. 001）. There were no differences in fasting blood-glucose and serum creatinine levels between the two groups（t=1. 010 and 0. 297, both P〉0.05）. The course of diabetes was longer in observation group than in control group（t=2. 579, P〈0.01）. ConclusionsThe relative factors for drug-induced hypoglycemia in elderly diabetic patients include older age, longer course of diabetes, lower body mass index, lower fasting blood-glucose level, poorer glycemic control and higher dose of sulfonamide treatment.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2014年第2期163-165,共3页
Chinese Journal of Geriatrics
关键词
糖尿病
2型
低血糖症
危险因素
Diabetes mellitus, type 2
Hypoglycemia
Risk factors
