摘要
目的探讨影响健脾理气法治疗原发性肝癌的预后因素,为健脾理气法治疗肝癌提供依据,并指导健脾理气法治疗方案的优化。方法回顾性分析2007年5月—2009年3月在广东省中医院接受健脾理气法治疗的151原发性肝癌患者的临床资料,对可能影响预后的各种因素进行单因素分析,将单因素分析中可能影响预后的指标依次引入COX比例风险模型进行多因素分析。结果全组患者1年生存率为21.85%,中位生存期为6.80个月,平均生存期是8.98个月。单因素分析显示,中医证型、就诊时症状、腹水情况、肿瘤类型、病灶比例、门脉癌栓、肝内转移、AFP水平、总胆红素分级、白蛋白分级、肝功能分级及中国肝癌分期等对预后有影响(P<0.05)。多因素分析表明,中医证型、腹水情况、肿瘤类型、门脉癌栓、甲胎蛋白(AFP)水平、肝功能分级及中国肝癌分期为影响肝癌预后的独立因素(P<0.05)。结论健脾理气法治疗肝癌的预后是由多种因素决定的,其中中医证型、腹水情况、肿瘤类型、门脉癌栓、AFP水平、肝功能分级及中国肝癌分期是影响其预后的主要因素。
Objective To evaluate the prognostic factors in treating primary liver cancer （PLC） patients by Pi-strengthening and qi-regulating method （PSQRM）, thus providing evidence and optimizing Pi-strengthening and qi-regulating program. Methods Clinical data of 151 PLC patients treated by PSQRM at Oncology Department, Guangdong Provincial Hospital of Traditional Chinese Medicine from May 2007 to March 2009 were retrospectively analyzed. The univariate analysis was determined to ana- lyze possible prognostic factors. Selected key factors were introduced into the COX proportional hazard model, and multivariate analysis was carried out. Results The 1-year survival rate was 21.85%, the median survival time was 6.80 months, and the mean survival time was 8.98 months. The univariate a- nalysis showed that Chinese medicine （CM） syndrome types, clinical symptoms at the initial diagnosis, ascites, tumor types, ratios of foci, portal vein tumor thrombus, intrahepatic metastasis, ^-fetoprotein （AFP） levels, total bilirubin classification, albumin classification, Child-Pugh classification, and domestic staging of liver cancer were significant prognostic factors （P 〈0.05）. The statistic data of multivariate a- nalysis indicated that CM syndrome types, ascites, tumor types, portal vein tumor thrombus, AFP lev- els, Child-Pugh classification, and domestic staging of liver cancer were independent factors influencing prognosis （P 〈0.05）. Conclusion The prognosis of PLC treated with PSQRM is determined by multiple factors including CM syndrome types, ascites, tumor types, portal vein tumor thrombus, AFP levels, Child-Pugh classification, and domestic staging of liver cancer.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2014年第2期162-166,共5页
Chinese Journal of Integrated Traditional and Western Medicine
基金
吴阶平医学基金会资助项目(No.320.6700.1124)
关键词
原发性肝癌
健脾理气法
预后分析
primary liver cancer Pi-strengthening and qi-regulating method prognostic analysis
