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预充回流试验法在剖宫产术腰硬联合麻醉中的应用

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摘要 目的探讨预充回流试验法在剖宫产术腰硬联合麻醉中的应用。方法择期拟行子宫下段剖宫产术患者100例,随机分为A、B两组,每组50例,A组行腰硬联合麻醉时,向硬膜外腔预充注入生理盐水3ml,观察Imin玻璃注射器内有无回流液及其性状;B组常规行腰硬联合麻醉。2组均蛛网膜下腔注射0.75%布比卡因,按序贯法进行试验,设定布比卡因初始剂量为9mg,剂量梯度为1.5mg,若上一例有效,则下一例递减1个剂量梯度,若无效则下一例递增1个剂量梯度,蛛网膜下腔阻滞有效的标准为注射布比卡因后20rain内阻滞上平面达L。采用概率单位法计算ED。结果预充回流液与麻醉效果存在相关关系。1例患者手术开始30rain发现回流液为血液,停止硬膜外注药;3例回流液性状为(+++),1例(++++),更换间隙重新穿刺,成功完成手术,有效避免了局麻药毒性反应。A组0.75%布比卡因的ED50为5.7mg(95%置信区间为4.6~7.2mg),B组0.75%布比卡因的ED50为8.2mg(95%置信区间为6.7~10.1mg),2组之间差异有统计学意义(P〈0.05)。结论预充回流试验法与麻醉效果相关,可及时监测并有效避免局麻药毒性反应、硬膜外水肿等并发症的发生,吲时能够增强剖宫产术患者腰麻的效果。
出处 《中华全科医学》 2014年第2期320-321,共2页 Chinese Journal of General Practice
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