摘要
目的探讨轻症支气管肺炎急性期IL-6在早期鉴别支原体肺炎中的意义。方法收集宁波市鄞州人民医院儿科2011年1月—2012年6月收治的轻症支气管肺炎患儿137例,其中支原体肺炎患儿62例,作为观察组,非支原体肺炎患儿75例,作为对照组,健康体检儿童30例,作为健康体检组。所有研究对象分别检查血常规、CRP、IL-6及相关临床指标,回顾性分析各组患儿的IL-6、CRP情况。结果所有患儿中支原体肺炎的发病率为45.26%。急性期支原体肺炎患儿IL-6水平较非支原体肺炎及健康体检组明显升高(P<0.05),急性期支原体肺炎CRP阳性患儿血清IL-6水平明显高于非支原体肺炎组CRP阳性患儿(P<0.05),急性期支原体肺炎CRP阴性患儿血清IL-6水平与非支原体肺炎组CRP阴性患儿间差异无统计学意义(P>0.05)。结论急性期入院的轻症肺炎患儿中若IL-6明显增高,则支原体感染的可能性大,若伴CRP同步增高则往往可以临床诊断支原体肺炎。
Abstract： Objective To explore the significance of interleukin-6 （ IL-6 ） in diagnosis of mycoplasma pneumonia （MPP） from the mild bronchial pneumonia at acute stage. Methods 62 patients with MPP, 75 patients with non mycoplasma pneumonia （NMPP） and 30 healthy volunteers were recruited. The concentration of IL-6 and C reactive protein（CRP） in serum were measured in acute stage and the correlation was analyzed. Results The incidence of MPP in all was 45.26%. The serum IL-6 level was significantly higher in MPP patients than that in healthy subjects and NMPP patients （P 〈 0.05 ）. The serum IL-6 level in MPP patients was positively correlated with the CRP levels （r = O. 41, P 〈 0.05 ）. The serum IL-6 level was significantly higher in MPP patients with abnormal CRP than that in NMPP patients （P 〈 0.05 ）. The serum IL-6 level in MPP patients was positively correlated with the CRP levels （r = 0.61, P 〈 0.05 ）. While the serum IL-6 and CRP levels were not different in two groups with normal CRP and no correlated with each other. Con- clusion If IL-6 was increased in acute stage of mild bronchial pneumonia, the possibility of mycoplasma infection in- creased. And if CRP rose simultaneously, the clinical diagnosis of MPP should be considered.
出处
《中华全科医学》
2014年第2期210-212,共3页
Chinese Journal of General Practice
基金
宁波市鄞州区科技局2010年第二批社会发展科技计划项目(鄞科[2010]75号)
关键词
支原体肺炎
白介素-6
C反应蛋白
Mycoplasma pneumonia
Interleukin-6
C reactive protein
