摘要
首次报道了用高效液相色谱法研究鲈鱼口服复方新诺明的药物代谢动力学特征。结果表明 ,鲈鱼单次口服剂量为200×10-6的复方新诺明后 ,其血液药物浓度 时间数据符合一室开放动力学模型。药物代谢动力学参数 :吸收速率常数 (ka)为0.096h -1、达峰时间 (Tmax)为21.479h,峰浓度 (Cmax)为50.768μg/ml、吸收半衰期 (T(1/2)Ka)为7.250h、消除半衰期 (T(1/2)K)为38.299h,药时曲线下面积 (AUC)为4138.400(mg·h)/L。鲈鱼口服药物0.5h后在肌肉、血液、肝脏、肾脏4种组织中就可以检测到药物的存在。药物在16h采样点4种组织里的浓度达最高。药物在肌肉、血液、肝脏中的平均回收率约80%～90 % ,该方法的检测限可达0.05×10-6。
This article first reports Pharmacokinetic of Sulfamethazine in Perch after oral administration by high performance liquid chromatography .The result demonstrates: dates of SMZ concentrations versus time were conformed to one compartment open model after a single oral administration at a dose of 200×10-6, and the primary parameters were shown bellow :Absorption rate constant (K a)was 0.096 h-1 . Time when maxium concentration was obtained(Tmax) was 21.479 h. Maxium concentration(Cmax)was 50.768 μg/ml, Absorption half life(T(1/2)Ka)was 7.250 h, Elimination half life(T(1/2)K)was 38.299 h, Area under serum concentration (AUC) was 4 138.400(mg·h)/L. We can determine the concentrations in four tissues (muscle, blood, liver and kinedy) after 0.5 h for administration and the maxium concentration was determined at 16 h after administration,Average recoveries were 80%-90% in muscle, blood and liver, and the limit of determination was 0.05×10-6.
出处
《海洋科学》
CAS
CSCD
北大核心
2001年第2期35-38,共4页
Marine Sciences
基金
农业部科研项目"鱼用药物代谢动力学及药物残留的研究"
