摘要
目的探讨2型糖尿病对肝硬化合并自发性细菌性腹膜炎(spontaneous bacterial peritonitis,SBP)患者血清细胞因子水平的影响。方法选择2010年12月—2012年12月我科住院的肝硬化合并SBP 52例,其中伴有2型糖尿病(糖尿病组)17例,不伴有2型糖尿病(非糖尿病组)35例。两组均于应用抗生素前检测血清白介素2(IL-2)、IL-4、IL-6、IL-8、IL-10、干扰素-γ(INF-γ)和肿瘤坏死因子-α(TNF-α)水平。结果糖尿病组血清IL-6、TNF-α水平高于非糖尿病组,IL-10水平低于非糖尿病组,差异有统计学意义(P<0.05),两组间其他细胞因子水平比较差异无统计学意义(P>0.05)。结论伴有2型糖尿病肝硬化患者细胞因子水平失衡,早期监测可为SBP早期诊断提供参考。
Objective To investigate the effect of type 2 diabetes mellitus on serum cytokine levels in patients with liver cirrhosis complicated with spontaneous bacterial peritonitis diabetes （SBP）. Methods A total of 52 patients with SBP complicated with liver cirrhosis during December 2010 and December 2012 in our hospital were divided into complicated with type 2 diabetes mellitus group （group A, n = 17） and non-diabetic group （group B, n = 35）. The serum levels of interleukin-2 （lL-2） , IL4, IL-6, IL-8, IL-10, interferon-γ （INF -γ） and tumor necrosis factor-α （TNF -α） were detected in the two groups before the antibiotics treatment. Results The serum levels of IL-6 and TNF -α in group A were significantly higher than those of group B, while the serum level of IL-10 was significantly lower than that of group B （P 〈 0. 05 ）. There were no significant differences in serum levels of IL-2, IL4, IL-8 and INF -γ between the two groups （P 〉 0. 05 ）. Conclusion The unbalance cytokine level of patients with liver cirrhosis complicated with type 2 diabetes mellitus can provide reference in diagnosis of SBP in early monitoring.
出处
《解放军医药杂志》
CAS
2014年第1期43-45,共3页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
关键词
肝硬化
糖尿病
2型
自发性细菌性腹膜炎
细胞因子类
Liver cirrhosis
Diabetes mellitus, type 2
Spontaneous bacterial peritonitis
Cytokines
