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他汀类药物治疗肺动脉高压—肺血管重构的近况 被引量：6

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摘要 他汀类药物即3-羟基-3-甲基戊二酰辅酶（HMG-CoA）还原酶抑制剂,是最广泛的降脂药物,除了降脂效果外,还具有抗炎、改善血管内皮、抑制细胞增殖及诱导细胞凋亡等作用。肺动脉高压是在炎性反应、异常血流剪切力、缺氧等因素的诱发下,细胞因子及血管活性物质产生异常,并作用于血管平滑肌细胞、血管内皮等靶细胞,导致肺血管异常收缩、生长和重构,细胞外基质堆积等一系列后果,最终形成肺动脉高压。
作者 张红艳 王安才
机构地区 皖南医学院弋矶山医院老年医学科
出处 《疑难病杂志》 CAS 2014年第2期210-212,共3页 Chinese Journal of Difficult and Complicated Cases
关键词 他汀类药物 肺动脉高压 血管重构
分类号 R543 [医药卫生—心血管疾病]
  • 相关文献

参考文献23

  • 1Archer SL, Weir EK, Wilkins MR. Basic science of pulmonary arterialhypertension for clinicians : new concepts and experimental therapies[J]. Circulation,2010,121 (18) :2045-2066.
  • 2Yao J,Xiong M,Tang B,et al. Simvastatin attenuates pulmonary vascularremodelling by down-regulating matrix metalloproteinase-l and -9 ex-pression in a carotid artery-jugular vein shunt pulmonary hypertensionmodel in rats[ J]. Eur J Cardiothorac Surg,2012,42(5 ) :el21-127.
  • 3Wilkins MR,Ali 0, Bradlow W, et al. Simvastatin as a treatment forpulmonary hypertension trial [ J ] . Am J Respir Crit Care Med ,2010,181(10) :1106-1113.
  • 4Chen D,Zhou D,Qian J,et al. Atorvastatin prevents dehydromonocrotal-ine-induced pulmonary hypertension in beagles [ J ]. Exp Lung Res,2012,38(7):333-343.
  • 5Reed RM,Iacono A,DeFilippis A, et al. Statin therapy is associated withdecreased pulmonary vascular pressures in severe COPD [ J ]. COPD,2011,8(2):96-102.
  • 6王凌玲,雷梦觉,涂燕平,邬甦.氟伐他汀对慢性阻塞性肺疾病患者合并肺动脉高压的治疗作用[J].中国老年学杂志,2011,31(9):1666-1667. 被引量：24
  • 7Omar FA, Ellena JG, Ghazwan SB, et al. Pleiotropic effects of statins indistal human pulmonary artery smooth muscle cells[ J]. Respiratary Re-search,2011,12( 1) : 137-137.
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  • 10Ward JPT, Mcmurtry. mechanisms of hypoxic pulmonary vasoconstrictionand their roles in pulmonary hypertension : new findings for an old prob-lem [J]. Curr Opin Pharmacol,2009 ,9(3) :287-296.

二级参考文献12

  • 1陆慰萱.肺动脉高压的新分类[J].中国实用内科杂志,2006,26(1):60-62. 被引量：12
  • 2中华医学会心血管病学分会 中华心血管病杂志编辑委员会.肺动脉高压筛查诊断与治疗专家共识[J].中华心血管病杂志,2007,35:979-987.
  • 3Rubin JL Diagnosis and management of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines[J]. Chest,2004 ; 126 : 7-10.
  • 4Shah DI,Singh M. Effect of bis(maltolato) oxovanadium on experimental vascular endothelial dysfunction [ J ] . Naunyn-Schmiedeberg' s Archives Pharmacol,2006 ;373:221 -9.
  • 5Taraseviciene-Stewart L, Scerbavicius R, Choi KH, et al. Simvastatin causes endothelial cell apoptosis and attenuates severe pulmonary hypertension[ J}. Am J Physiol Lung Cell Mol Physiol,2006 ;291 :L668-76.
  • 6Haleox JP, Deanfield JE. Beyond the laboratory: clinical implications for statin pleiotropy [ J]. Circulation,2004 ; 109 : 1142-48.
  • 7Li J. Clinical implications for statin pleiotropy [ J ]. Curr Opjn Lipidol, 2005 ;16:624-9.
  • 8Nishimura T, Vaszat LT, Faul JL. Simvastatin reduces rats from fatal pulmonary hypertension by inducing apoptosis of neointimal smooth muscle ceils[ J]. Circulation,2003 108 : 1640-5.
  • 9TakahisaM, Kazuya K, Masatoshi H, et al. Statin protects endothelial nitric oxide Synthase activity in hypoxia-induced pulmonary hypertension [ J]. Arteriscler Thromb Vasc Biol,2005 ;25:2335-42.
  • 10Hemandez PO ,Perez S,Soria E ,et al. Involvement of Rho GTPase in the transcriptional inhibition of prepmendothelin-1 gene expression by simvastatin in vascular endothelial cells[ J]. Circ Res ,2000 ;87:616-22.

共引文献23

同被引文献86

引证文献6

二级引证文献32

疑难病杂志
2014年 第2期

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