摘要
目的:研究高危型人乳头状瘤病毒与吲哚胺2,3-二氧酶在宫颈上皮内瘤变组织中表达情况。方法:采用第二代杂交捕获法检测高危型HPV,免疫组化法检测吲哚胺2,3-二氧酶表达。结果:高危型HPV感染与吲哚胺2,3-二氧酶同时阳性的患者占62.91%(95例/151例),同时阴性的患者占21.85%(33例/151例)。高危型HPV感染阳性的患者宫颈组织中吲哚胺2,3-二氧酶阳性表达率显著高于高危型HPV感染阴性患者(χ2=62.1833,P<0.01)。高危型HPV与吲哚胺2,3-二氧酶表达有相关性(r=0.9611,P<0.05)。结论:高危型HPV联合吲哚胺2,3-二氧酶在宫颈上皮内瘤变的疾病发生、发展过程中起到重要作用。
Objectives： To study the expression of high - risk human papilloma virus （ HR - HPV） and in- doleamine 2,3 -dioxygenase （IDO） in cervical intraepithelial neoplasia （CIN）. Method： HR- HPV was detected by second- generation hybrid capture. IDO was detected by immunohistochemistry. Results： HR- HPV infection and IDO positive patients accounted for 62.91% （95/151 ）, while negative patients accounted for 21.85% （33/ 151 ）. The expression of IDO in HR - HPV positive patients was significantly higher than that in HR - HPV negative patients （χ2 =62. 1833, P 〈0.01 ）. The overexpression of IDO was positively correlated with HR- HPV infection in CIN （r =0.9611, P 〈0.05）. Conclusion： HR- HPV and IDO play an important role in the development of CIN.
出处
《中国性科学》
2014年第1期41-43,共3页
Chinese Journal of Human Sexuality
基金
黑龙江省卫生厅支撑项目(2011-622)
关键词
宫颈上皮内瘤变
高危型人乳头状瘤病毒
吲哚胺2
3-二氧酶
Cervical intraepithelial neoplasia
High - risk human papilloma virus
Indoleamine 2,3 - dioxygenase
