摘要
目的 研究儿童急性白血病细胞多药耐药基因mdrl表达与临床化疗疗效及预后的关系。方法 应用半定量RT-PCR技术动态观察33例儿童急性白血病mdrl基因表达，以mdrl/β2M值评价mdrl表达水平。结果 难治复发组mdrl基因阳性表达率及表达水平明显高于初治组和缓解组。结论 mdrl基因表达水平的高低与白血病难治程度及复发有关。对临床选择化疗方案及判断预后有一定指导意义。
Objective To study the relation between multidrug resistance gene mdrl and curative effects of chemotherapy and pro gnosis in children with acute leukemia.Methods mdrl mRNA expression in 33 children with acute leukemia was observed closely by semi-quantitative m ethod-RT-PCR,and the levels of mdrl were evaluated with the ratio of mdrl/β2M.Results The mRNA positive rate and ex pression levels of mdrl in refractory and relapse cases were significantly higher than those in first-visit and remission cases.Conclusion The expression lev els of mdrl mRNA might be related to refractory de gree and relapse in leukemia,which also has clinical guid ance significance in selecting chemotherapy methods and predicting prognosis.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2001年第1期8-9,共2页
Journal of Applied Clinical Pediatrics
基金
湖北省重点科技攻关研究基金资助(项目编号:961P1903)
