摘要
观察高脂、高胆固醇膳食和有氧游泳运动对大鼠脂代谢的影响 ,深入探讨与高脂血症发生密切相关的载脂蛋白A -I、载脂蛋白B基因在饮食诱导的高脂血症实验动物体内表达的变化 ,并与有氧运动对它们的影响作对比研究。结果表明 ,高脂饮食组肝脏apoA -ImRNA水平显著低于对照组 ;高脂运动组显著高于高脂不运动组 ;8周高脂饮食和 /或有氧运动没有显著上调或下调大鼠肝脏apoBmRNA的水平。结果提示 ,运动可在转录水平对抗高脂负荷下调大鼠肝脏apoA -I表达的作用 。
To investigate the molecular mechanism of aerobic exercise in improving diet-induced hyperlipidemia, we investigate the effects of high-fat-high-cholesterol (HFC) diet and long-term swimming training on the lipid metabolism.The results show that: the levels of hepatic apoA-I mRNA in 8-week high fat diet(HS) group are lower than 8-week normal diet(NS) group (P < 0.01 ).The hepatic mRNA levels of apoA-I of 8-week high fat diet plus exercise(HE) group were higher than HS group (P< 0.01 ).But there is no difference in apoB mRNA level among all groups.It is suggested that:1) neither HFC diet nor swimming training regulates the hepatic apoB gene transcription; 2) HFC diet can down-regulate the hepatic transcription of apoA gene in rats.Swimming training may protect against the atherogenic effects of HFC diet through up-regulating the hepatic transcription of apoA-I gene.
出处
《中国运动医学杂志》
CAS
CSCD
北大核心
2001年第1期9-11,18,共4页
Chinese Journal of Sports Medicine
基金
天津市自然科学基金资助项目!(NO 9836 0 811)
关键词
有氧运动
高脂血症
肝脏
载脂蛋白
基因表达
aerobic exercise,hyperlipidermia,liver,apolipoproteins,gene expression
