摘要
目的探讨肺脓肿和支气管扩张合并感染患者行支气管肺泡灌洗疗法的临床效果研究,为临床治疗提供参考。方法选取医院2013年1-11月支气管扩张合并感染患者104例,按治疗方法的不同分为治疗组和对照组,每组各52例,所有患者均进行祛痰药及抗菌药物等常规治疗,治疗组在常规治疗基础上实施支气管肺泡灌洗疗法,对照组进行体位引流排痰法,比较两组患者的氧合指数(PaO2/FiO2)、动脉血氧分压(PaO2)、血氧饱和度(SaO2)等指标变化、治疗过程中并发症的发生及临床治疗效果,数据采用SPSS17.0软件进行统计分析。结果治疗前治疗组的PaO2/FiO2、PaO2、SaO2指标与对照组比较,差异均无统计学意义;治疗后治疗组的PaO2/FiO2为324.00±27.00显著高于对照组277.00±25.00,治疗组的PaO2(88.04±15.37)mm Hg显著高于对照组(70.47±11.23)mm Hg,治疗组的SaO2(93.41±5.53)%显著高于对照组(87.21±5.09)%,差异均有统计学意义(P<0.05);治疗组并发症发生率5.8%,显著低于对照组的19.2%,差异有统计学意义(χ2=4.31,P<0.05);治疗组总有效率82.7%,显著高于对照组的55.8%,差异有统计学意义(χ2=5.34,P<0.05)。结论肺脓肿和支气管扩张合并感染患者行纤维支气管镜支气管肺泡灌洗疗法,临床效果确切,安全可靠,值得临床推广。
OBJECTIVE To explore the clinical efficacy of bronchoalveolar lavage in treatment of pulmonary abscess and bronchiectasis complicated with infections so as to provide guidance for clinical treatment. METHODS A total of 104 cases of bronchiectasis complicated with infections, who were treated in the hospital from Jan to Nov, 2013, were enrolled in the study and divided into the treatment group and the control group, with 52 cases in each, then all the subjects received conventional therapies such as expectorant drugs therapy and antibiotics therapy, the treatment group was treated with additional bronchoalveolar lavage on the basis of the conventional therapies, the control group was given the postural drainage expectoration therapy, the oxygenation index （PaO2/ FiO2）, arterial oxygen partial pressure （PaO2）, and oxygen saturation （SaO2） were observed and compared between the two groups, the incidence of complications during the treatment and the therapeutic effect were analyzed, and the statistical analysis was performed with the use of SPSS17. 0 software. RESULTS Before the treatment, the difference in the PaO2/FiO2, PaO2, or SaO2 nt between the treatment group and the control group was not statistically significant. After the treatment, =t=27.00）, significantly higher than （277.00d：25.00） of the PaO2/FiO2 of the treatment group was （324. 00 the control group~ the PaO2 of the treatment group was （88.04 ＋15.37）mmHg, significantly higher than （70.47~11.23）mmHg of the control group; the SaO2 of the treatment group was （93.41 -＋- 5.53） ~, significantly higher than （87.21 -f- 5.09） % of the control group, the differences were statistically significant（P^0.05）. The incidence of complications was 5.8~ in the treatment group, significantly lower than 19.2~ in the control group, with statistical significance （Z2 = 4.31, P〈0.05）.The total effective rate was 82.7~ in the treatment group, significantly higher than 55.80/00 in the control group, with statistical signi{icanee （%2 = 5.34, P^0.05）. CONCLUSION The hronchoscopic bronchoalveolar lavage thera- py can achieve accurate clinical efficacy in treatment of pulmonary abscess and bronchiectasis complicated with in- fections, with the safety reliable, and it is worthy to be promoted in the hospital.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2014年第4期895-897,共3页
Chinese Journal of Nosocomiology
基金
浙江省中医药优秀青年人才基金项目(2013ZQ028)
关键词
支气管肺泡灌洗
肺脓肿
支气管扩张
感染
临床疗效
Bronchoalveolar lavage
Pulmonary abscess
Bronchiectasis
Infection
Clinical efficacy
