摘要
目的 :探讨慢性肾功能不全 (CRF)患者细胞免疫功能状况 ,以及血液透析 (血透 )的影响。方法 :应用酶联免疫吸附 (EL ISA)双抗体夹心法检测 30例 CRF未透析患者和 6 2例血透患者血透前后及对照组血清可溶性白介素 α受体 (SIL 2 R)、白介素 6 (IL 6 )和肿瘤坏死因子 α(TNFα)水平。结果 :与对照组相比 ,CRF未透析患者和血透患者血清 SIL 2 R、IL 6和 TNFα水平均显著增高 ;CRF未透析患者与血透患者血清SIL 2 R、IL 6和 TNFα水平间比较无显著差异 ;血透患者血透前后血清 IL 6和 TNFα水平无显著差异 ,血清 SIL 2 R较透前显著增高。结论 :CRF患者均存在显著的细胞免疫功能紊乱 。
Objective:To investigate the effects of hemodialysis (HD) on cellular immunological function in patients with chronic renal failure (CRF).Methods:Enzyme linked immunoadsorbent assay(ELISA) method was used to detect the serum soluble interleukin2 receptor(SIL2L),interleukin6(IL6)and tumor necrosis factorα(TNFα) level in 30 CRF patients without HD,62 patients with HD and 20 normal controls.Results:When compared with the control group,serum SIL2R,IL6 and TNFα levels were significantly higher in all CRF patients with or without HD and no significant difference was observed between groups.Serum SIL2R increased significantly after HD compared with that before HD,and IL6 and TNFα had no significant difference in patients before and after HD.Conclusions:The cellular immunodeficiency was observed in CRF patients and single HD therapy may have some effects on enhancing immunofunction in these patients.
出处
《中国危重病急救医学》
CAS
CSCD
2001年第1期10-11,共2页
Chinese Critical Care Medicine
基金
卫生部科研基金资助项目! (No.96 2 12 8)
关键词
肾功能衰竭
血液透析
白介素-2受体
肿瘤坏死因
chronic renal failure
hemodialysis
soluble interleukin2 receptor
interleukin6
tumor necrosis factorP
