摘要
目的 :探讨体内淋巴细胞微核形成与肺癌个体遗传易感性的关系。方法 :本组病例 -对照研究包括 95例确诊肺癌患者和90例对照。按末梢血微核法制备微核片。结果 :肺癌患者的自发和吸烟诱发的微核率 (MNF ,0 87‰和 1 6 4‰ )比对照人群的(0 47‰和 0 76‰ )有显著增加 (分别P <0 .0 5和P <0 .0 1)。结论 :肺癌患者是诱变效应易感人群 ;同时本研究首次证实 ,体内淋巴细胞微核形成是评价肺癌个体易感性的良好生物标志 ,MNF为 1‰和≥ 3‰的个体分别增加 5 5倍和 2 1 9倍的发生肺癌的相对危险性。
Purpose: To investigate the association of the in vivo micronucleus formation in lymphocytes of human peripheral blood with lung cancer. Methods: Case-control study included 95 patients with lung cancer and 90 controls. Slides were prepared by the in vivo micronucleus test in capillary blood lymphocytes. Results: Spontaneous and induced by smoking micronucleus frequencies(MNF) in lung cancer patients(0.87‰ and \{1.64‰\})are significantly higher than those in controls(0.47‰ and 0.76‰)(P<0.05 and P<0.01). Conclusion: Patients with lung cancer were susceptible to mutagens; In this study we confirmed first that the in vivo micronucleus formation in lymphocyte of peripheral blood is an excellent biomarker in assessing individual cancer susceptibility, persons with 1‰ and 3‰ of MNF had an increase of 5.5-fold and 21.9-fold higher relative risk for lung cancer.
出处
《癌变·畸变·突变》
CAS
CSCD
2001年第1期20-22,共3页
Carcinogenesis,Teratogenesis & Mutagenesis
基金
江苏省卫生厅科研基金资助项目(H9527)
关键词
肺癌
微核
遗传易感性
lung cancer
micronucleus
genetic susceptibility
