摘要
为探讨端粒酶活性与胃癌发生的关系 ,本文以改良TRAP法对 4 3例胃粘膜活检标本的端粒酶活性进行检测 ,结果发现 :胃癌的端粒酶阳性率为 87% ( 2 0 / 2 3) ,萎缩性胃炎的端粒酶阳性率为 2 8 6% ( 2 / 7) ,而中度胃炎与浅表性胃炎无一例阳性 ,它提示端粒酶活性的检测对于胃癌的诊断可能具有重要意义。
Telomerase activity in 43 biopsy of gastric mucosa was detected with the modified telomeric repeat amplification protocol(TRAP) assay to elucidate pathogenesis of gastric cancer.The detected positive rates were as follows:87%(20/23) in gastric cancer,28 6%(2/7) in moderate and non-typical gastritis ,0%(0/10 in atrophic and superficial gastritis,respectively.These results suggest that the detection of telomerase activity may play a significant role in the diagnosis of gastric cancer.
出处
《中国医师杂志》
CAS
2000年第12期723-724,共2页
Journal of Chinese Physician
关键词
胃肿瘤
端粒酶
实验室诊断
胃粘膜活检
Gastric tumor,cancer
Telomerase
Laboratory diagnosis
Gastric mucosa biopsy
