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The fate of regulatory T cells： survival or apoptosis

The fate of regulatory T cells： survival or apoptosis
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摘要 Foxp3＋ regulatory T cells （Tregs） are unique in their immunosuppressive abilities and contribution to immune regulation. However, the homeostatic processes and survival programs that maintain the Treg population remain unclear. Here, we highlight the recent study by Pierson et al.,1 which dissected the regulatory mechanisms of Treg home- ostasis and survival. Foxp3＋ regulatory T cells （Tregs） are unique in their immunosuppressive abilities and contribution to immune regulation. However, the homeostatic processes and survival programs that maintain the Treg population remain unclear. Here, we highlight the recent study by Pierson et al.,1 which dissected the regulatory mechanisms of Treg home- ostasis and survival.
作者 Chia-Rui Shen Wei-Cheng Yang Hsin-Wei Chen
机构地区 Department of Medical Biotechnology and Laboratory Science and Graduate Institute of Biomedical Science National Institute of Infectious Diseases and Vaccinology Graduate Institute of Immunology
出处 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2014年第1期11-13,共3页 中国免疫学杂志（英文版）
分类号 Q2 [生物学—细胞生物学] Q255 [生物学—细胞生物学]
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  • 1Pierson W, Cauwe B, Policheni A, Schlenner SM, Franckaert D, Berges J et al. Antia- poptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells. Nat Immunol 2013; 14: 959-965.
  • 2Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immuno12003; 4: 330-336.
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Cellular & Molecular Immunology
2014年 第1期

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