摘要
目的探讨阴茎转移癌的临床特点、诊治方法及预后。方法回顾性分析18例阴茎转移癌患者的临床及随访资料并复习相关文献。18例患者原发肿瘤包括膀胱癌8例，前列腺癌4例，直肠癌2例，结肠癌、肾癌、食管癌和肺癌各l例。其中9例患者接受了阴茎切除＋静脉化疗，5例患者仅接受静脉化疗未行阴茎切除术，2例患者仅接受了阴茎局部放疗，1例肾癌患者仅接受了索拉菲尼靶向治疗。结果本组18例患者中，从确诊原发肿瘤至出现阴茎转移时间为1～100月，平均（18．7±1．9）月。从确诊阴茎转移至患者死亡时间为4～23月，平均（10．2±1．7）月。所有18例患者均死于出现阴茎转移2年内。结论阴茎转移癌是一种罕见且预后较差的疾病，即使进行治疗，多数患者仍死于确诊阴茎转移1年内。逆行性静脉途经是发生阴茎转移的主要机制。阴茎切除仅限于缓解局部症状而不应常规应用。
Objective To discuss the clinical features, diagnosis, treatment and outcome of patients with metastatic tumor to the penis. Methods The medical records of 18 patients with metastatic penile carcinoma between 1998 and 2012 were ana- lyzed. The primary sites were as follows： 8 urothelial carcinomas of urinary bladder,4 prostatic carcinomas,3 colorectal adeno- carcinomas, 1 pulmonary carcinomas, 1 renal cancer and 1 esophagus cancer. 9 patients received total penectomy combined with systemic chemotherapy,2 patients external beam radiotherapy,and 5 patients chemotherapy. Results The interval between primary cancer and penile metastases ranged from 1 to 100 months （mean 18.7± 1.9 months）. The interval between penile me- tastases and death ranged from 4 to 23 months （mean 10.2 ± 1.7 months）. All patients diagnosed with penile metastasis died within 2 years. Gonclusions Penile metastasis is rare and represents a challenging problem. The common mode of metastasis to the penis is retrograde venous route. The overall outcome is very poor,and most patients will die within 1 year despite sys- temic chemotherapy and supportive care. Radical ablative surgery is justified only for symptomatic relief.
出处
《现代泌尿外科杂志》
CAS
2014年第2期93-95,共3页
Journal of Modern Urology
关键词
阴茎肿瘤
肿瘤转移
阴茎转移癌
预后
penile cancer
penile metastasis
penile secondary tumor
outcome
