摘要
乙型肝炎病毒(hepatitis B virus,HBV)是引起肝硬化的主要原因之一。HBV感染致肝细胞损伤,炎症介质激活肝星状细胞,大量细胞外基质过度沉积形成肝纤维化,慢性炎症持续存在推进受损肝脏的纤维化和肝硬化进程。近年来,乙型病毒性肝炎(乙肝)肝纤维化和肝硬化的无创诊断技术得到发展;抗病毒治疗、抗纤维化治疗进一步完善;对肝纤维化及早期肝硬化的可逆转性已达成共识。国际肝病病理研究组织近期提出的进展期新概念使人们对肝硬化有了新的认识。
Hepatitis B virus （HBV） infection is one of the main causes for liver cirrhosis that can induce hepatic damage and lead to hepatic stellate cell activation. Excessive extracellular matrix accumulation causes hepatic fibrosis and chronic inflammation accelerates the process of fibrosis and cirrhosis. Recently, non-invasive diagnostic techniques for HBV-assoeiated liver fibrosis and cirrhosis have been developed; it has been clear that liver fibrosis and early cirrhosis can be repressed by antiviral and anti-fibrosis treatments. The International Liver Pathology Study Group proposed new concepts with new understanding of liver cirrhosis.
出处
《中国病毒病杂志》
CAS
2014年第1期7-10,共4页
Chinese Journal of Viral Diseases
基金
国家"十二五"艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2013ZX10002004)
