摘要
目的：探讨纤维蛋白原（FIB）和血小板平均体积（MPV）与急性脑梗死（ACI）的关系。方法：分析429例ACI患者（ACI组）和429例非脑梗死患者（对照组）的血小板和凝血系统相关参数水平，并根据ACI组的美国国立卫生研究院卒中量表（NIHSS）评分将ACI组分为轻、中、重度亚组。结果：与对照组比较，ACI组的PLT水平显著降低（P〈0．01），MPV、血小板分布宽度（PDW）及纤维蛋白原（FIB）水平显著升高（P〈0．01）。多因素Logistic回归分析显示，MPV和FIB与脑梗死呈独立相关（OR=1．628，95％CI为1．427～1．857；OR=7．115，95％C1为4．981～10．164）；FIB与MPV水平两者相互间无明显相关性。ACI组各亚组FIB水平两两比较差异有统计学意义（P〈0．01），ACI患者FIB水平与NIHSS评分呈正相关（r=0．451，P〈0．01）。结论：FIB、MPV可能为引起急性脑梗死的重要危险因素，且FIB与病情的严重程度呈显著正相关．
Objective： To investigate the relationship of fibrinogen （FIB）, mean platelet volume （MPV） and acute cerebral infarction （ACI）. Methods： The level ofplatelets system platelets （PLT）, MPV, plateletcrit, platelet distri- bution width （PDW） and the coagulation system （prothrombin time, international normalized ratio, FIB, activated partial thromboplastin time） of 429 ACI cases （ACI group） and 429 cases of Non-cerebral infarction group （con- trol group） were analyzed. According to the National Institutes of Health stroke Scale （NIHSS） in ACI pa- tients, the ACI group was divided into mild, moderate and severe subgroups. Results： Compared with the con- trol group, the PLT levels were significantly lower （P〈0.01） whereas the MPV, PDW and FIB levels were signif- icantly higher （P〈0.01） in ACI group. Logistic regression analysis showed that MPV and FIB were independently associated with ACI （OR = 1.628, 95% C1：1.427-1 .857; OR = 7.115,95% CI ：4.981-10.164）. The FIB level showed no significant correlation with MPV level. The FIB levels between the subgroups of ACl group were sig- nificantly different （P〈0.01）. In ACI patients, the FIB levels and NIHSS score were positively correlated （r = 0.451, P〈0.01）. Conclusion： FIB and MPV levels may be the important risk factors for ACI.
出处
《神经损伤与功能重建》
2014年第1期20-23,共4页
Neural Injury and Functional Reconstruction
