摘要
背景:作为淫羊藿主要有效成分之一的淫羊藿苷,对于骨损伤后的修复具有重要作用。淫羊藿苷在体内的持续有效浓度对于骨损伤的修复至关重要。目的:综述近年国内外淫羊藿苷对于骨修复的研究进展,探讨淫羊藿苷的药理活性浓度。方法:第一作者应用计算机检索2000年1月至2013年10月PubMed数据(http://www.ncbi.nlm.nih.gov/PubMed)及CNKI中国期刊全文数据库(http://www.cnki.net/)有关淫羊藿苷对骨组织修复作用,或者与淫羊藿苷治疗骨损伤的相关基础研究文献。英文检索词"icariin,concentration,bone";中文检索词"淫羊藿苷,浓度,骨"。排除重复性研究,共检索到76篇相关文献,44篇文献符合纳入标准。结果与结论:利用淫羊藿苷的有效活性成分联合缓释支架材料,可以诱导骨髓间充质干细胞成骨分化,增强成骨细胞活性,抑制破骨细胞的吸收,从而起到修复骨组织的作用。淫羊藿苷促进细胞分化作用虽已得到肯定,但是否具有促进细胞增殖作用还存在一定的争议。研究发现,淫羊藿苷的药理活性浓度从10-8到10-5 mol/L不等,总体来看,10-8-10-5 mol/L应该是淫羊藿苷发挥其最佳药理活性可能出现的区间,但目前临床试验尚未开展,具体的持续给药浓度还不确定,这些都需要进一步研究探索。
BACKGROUND： As one of the main active ingredients in epimedium, icariin plays an important role in bone defect repair. Sustained and effective concentration of icariin in vivo is essential for bone damage repair.
OBJECTIVE： To recommend the research progress of epimedium glycoside for bone repair and to explore the pharmaco-active concentration of icariin.
METHODS： A computer-based online search of CNKI database （http：//www.cnki.net/） and PubMed database （http：//www.ncbi.nlm.nih.gov/PubMed） from January 2000 to October 2013 was performed for related articles of the effect of icariin for bone defect repair and bone damage repair. The key words were ＂icariin, concentration, bone＂ in Chinese and English. After repeated articles were excluded, 76 related articles were screened out and 44 of them met the inclusive criteria.
RESULTS AND CONCLUSION： The icariin-released scaffold materials can induce the osteogenic differentiation of bone marrow-derived mesenchymal stem cells, promote the viability of osteoblasts and inhibit the resorption of
osteoclasts, thus repairing bone tissue. It is certain that icariin promotes cellular differentiation, however whether it can promote cellular proliferation remains unclear. The pharmaco-active concentration of icariin ranges from10-8 to 10-5 mol/L, but clinical trial has not yet been carried out, and specific drug concentration is uncertain, which needs further exploration.
出处
《中国组织工程研究》
CAS
CSCD
2014年第2期301-306,共6页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金资助项目(81072958)~~
