摘要
背景：对于胶体果胶铋干混悬剂治疗幽门螺杆菌（Hp）阳性消化性溃疡的疗效是否优于胶体果胶铋胶囊，目前尚无相关的临床研究。目的：比较胶体果胶铋干混悬剂与胶体果胶铋胶囊对Hp阳性消化性溃疡的临床疗效。方法：选取2012年1月～2013年4月中南大学湘雅二医院门诊初治的126例Hp阳性的消化性溃疡患者，随机分为观察组和对照组，分别给予胶体果胶铋干混悬剂＋标准三联方案以及胶体果胶铋胶囊＋标准三联方案，评估比较临床症状缓解情况、内镜下溃疡愈合情况以及Hp根除率。结果：观察组患者胃溃疡（84．6％对55．6％）、十二指肠溃疡（84．8％对62．1％）2周末症状消失率均显著高于对照组（P〈0．05），但两组4周末症状消失率无明显差异（P〉0．05）。观察组的溃疡治疗总有效率（98．2％对84．0％）、总体Hp的PP根除率（89．5％对72．7％）和ITT根除率（81．O％对63．5％）均显著高于对照组（P〈0．05）。两组均未见严重不良反应。结论：胶体果胶铋干混悬剂治疗Hp阳性消化性溃疡的疗效优于胶体果胶铋胶囊。
Background： There is no clinical study whether colloidal bismuth pectin suspension is more effective than colloidal bismuth pectin capsule for the treatment of Helicobacter pylori （Hp） positive peptic ulcer. Aims： To compare the clinical efficacy of colloidal bismuth pectin suspension and colloidal bismuth pectin capsule for the treatment of Hp positive peptic ulcer. Methods： A total of 126 untreated Hp positive peptic ulcer patients from January 2012 to April 2013 at The Second Xiangya Hospital of Central South University were enrolled in this study. Patients were randomly divided into observation group and control group. Patients in observation group were given colloidal bismuth pectin suspension combined with standard triple therapy, while patients in control group were given colloidal bismuth pectin capsule combined with standard triple therapy. The efficacies on symptom alleviation, ulcer healing and Hp eradication were assessed and compared between the two groups. Results： The symptom alleviation rates of gastric ulcer （84.6% vs. 55.6% ） and duodenal ulcer （84.8% vs. 62.1% ） after 2-week treatment in observation group were significantly higher than those in control group （P 〈 0.05 ）. However, no significant differences were found after 4-week treatment （ P 〉 0.05 ）. The overall effective rate of peptic ulcer （98.2% vs. 84.0% ）, overall PP （89.5% vs. 72.7% ） and ITr （81.0% vs. 63.5% ） Hp eradication rates in observation group were significantly higher than those in control group （ P 〈 0.05 ）. No serious adverse reactions were observed in both groups. Conclusions： The therapeutic efficacy of colloidal bismuth pectin suspension is significantly higher than colloidal bismuth pectin capsule for treating Hp positive peptic ulcer.
出处
《胃肠病学》
2014年第1期32-35,共4页
Chinese Journal of Gastroenterology
关键词
胶体果胶铋
幽门螺杆菌
消化性溃疡
治疗
Colloidal Bismuth Pectin
Helicobacter pylori
Peptic Ulcer
Therapy
