摘要
背景:氧化锌具有较好的抗菌效果,然而对其抗菌机制的研究相对较少,关于其安全性目前尚未得到很好确认。目的:总结氧化锌的抗菌机制及其安全性研究进展。方法:分别以"氧化锌或ZnO,抗菌","氧化锌或ZnO,安全性"和"zinc oxide or ZnO","zinc oxide or ZnO,antibacterial,safety"为关键词进行检索,应用计算机检索CNKI和Pubmed数据库中2005年1月至2013年8月的相关文章,选择内容与氧化锌抗菌及其安全性相关的文献。结果与结论:氧化锌的抗菌机制较为复杂,目前认为主要通过光催化作用、锌离子溶出、活性氧的产生3种途径而发挥抗菌作用,特别是关于活性氧产生与光照之间的关系,不同的研究具有不同的结果,因此对其抗菌机制的研究有待进一步加强。针对氧化锌的安全性,不同的作用对象具有不同的实验结果,目前尚没有统一的结论,但在部分研究中氧化锌表现出一定的毒性,因此对氧化锌的安全性研究需要进一步加强。
BACKGROUND： Zinc oxide has shown extraordinary antibacterial effect. But the antibacterial mechanisms of zinc oxide have not been well developed, and the safety of zinc oxide has not yet been confirmed.
OBJECTIVE： To summarize the antibacterial mechanism and safety of zinc oxide based on the current research situation of zinc oxide.
METHODS： The CNKI database and PubMed database （2005-01/2013-08） were used to search the related articles about zinc oxide antibacterial mechanism and safety. The retrieval keywords were ＂zinc oxide or ZnO, antibacterial＂, ＂zinc oxide or ZnO, safety＂ both in English and Chinese.
RESULTS AND CONCLUSTION： The antibacterial mechanism of zinc oxide is complex. Zinc oxide reveals its antibacterial power by photo catalysis, zinc ion dissolve out, and active oxygen. But the relationship between photo catalysis and active oxygen is different based on different studies. The safety of zinc oxide is not confirmed, and different studies have different results. Especially for the nano-zinc oxide, some studies have showed that the zinc oxide is toxic. All of these mean much more researches are needed to verify the safety of zinc oxide.
出处
《中国组织工程研究》
CAS
CSCD
2014年第3期470-475,共6页
Chinese Journal of Tissue Engineering Research
