摘要
器官移植的最终目的是获得移植器官的长期存活耐受而无免疫排斥。mTOR信号通路在器官移植免疫中起重要作用。雷帕霉素作为mTOR抑制剂可抑制T细胞激活、促进调节性T细胞增殖、抑制树突状细胞成熟,发挥抗排斥作用。雷帕霉素以其无肾毒性以及抗内皮细胞增殖等特性使临床获得了减轻甚至预防CNIs肾毒性和抗肿瘤的新途径,为肝移植受者免疫抑制方案提供了新的解决途径。
The final objective of organ transplantation is to obtain transplanted organ long-term surviving without immunologic rejection. As we know that mTOR signal path plays an important role in organ transplantation immunity. As an inhibitor of roTOR, rapamycin suppress T cell stimulation, promote regulatory T cell proliferation, inhibit dendritic cell maturation, and plays anti-rejection roles. Less renal toxicity, anti endothelial cell proliferation and other features of rapamycin suggest a new way to reduce or even prevent CNIs renal toxicity and antitumor, and provide a new solution to liver transplant recipients in immunosuppressive regimen.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2014年第1期79-83,共5页
Immunological Journal
基金
南京军区重点课题(12Z15)
关键词
雷帕霉素
免疫排斥
肝移植
Rapamycin
Immunologic rejection
Liver transplantation
