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树突细胞与细胞因子诱导的杀伤细胞过继免疫联合化疗治疗多发性骨髓瘤 被引量:5

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摘要 目的探讨树突细胞(DC)与细胞因子诱导的杀伤细胞(CIK)过继免疫联合化疗治疗多发性骨髓瘤的临床效果。方法将60例多发性骨髓瘤患者随机分为常规化疗组(A组),DC与CIK过继免疫联合化疗治疗组(B组),每组30例。比较两组治疗前后的免疫指标与临床疗效。结果60例患者治疗后的热休克蛋白70的表达水平、Thl/Th2、转移生长因子-β(TGF-β)及CD4+CD25+细胞百分比与治疗前比较,差异有统计学意义(P〈0.05);治疗后,A组患者的生活质量(PS评分)、瘤细胞百分比、β2微球蛋白表达水平(β2-MG)、尿液轻链及血清肌酐水平(Scr)与B组比较,差异均有统计学意义(P〈0.05)。结论多发性骨髓瘤患者采用树突细胞与细胞因子诱导的杀伤细胞过继免疫进行治疗,与化疗具有协同作用,能有效缓解肿瘤细胞的免疫的抑制,疗效显著,值得临床推广应用。
作者 党惠兵
出处 《中国实用医刊》 2014年第4期65-66,共2页 Chinese Journal of Practical Medicine
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